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Synthese et reactions de N-acylphosphoramides apparentes aux ceto-4 diaza-1,3 phospholanes-2
Mulliez, Michel
, p. 1211 - 1218 (2007/10/02)
A new, general method, more efficient than previous ones, for the synthesis of N-acylphosphoramides 3, by reacting the silylated primary phosphoramides 2 with carboxylic chlorides is described (Figure 2).It is applied to the synthesis of precursors B and C and acyclic analogs D and E of the 4-keto 1,3-diaza, 2-phospholanes A (Figure 1). 3c (B) and 3a (C) lead to 15 (A) (Figure 5) and 17 (Figure 6) (A) in presence of sodium hydride, and hydrogen with palladium on charcoal as catalyst, respectively.Phosphorane 19 is formed from 3a and triphenylphosphine (Figure 6).D and E are not phosphorylating reagents but acylating ones.
