791076-24-9

Upstream product

• 1349877-39-9 ethyl N-[(E)-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}(cyanoimino)methyl]glycinate 
• 611-17-6 1-bromomethyl-2-chlorobenzene 
• 309956-78-3 (R)-piperidin-3-ylcarbamic acid tert-butyl ester 

Downstream Products

• 791076-21-6 ethyl 4-amino-2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate 
• 1349877-51-5 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylic acid 
• 1349877-52-6 tert-butyl [(3R)-1-{5-[(2-bromophenyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate 
• 1349877-55-9 tert-butyl [(3R)-1-{5-[(2-bromophenyl)(methyl)carbamoyl]-1-(2-chlorobenzyl)-1H-imidazol-2-yl}piperidin-3-yl]carbamate 
• 853070-26-5 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazole-5-carboxylic acid 
• 1349877-56-0 tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate 
• 1349877-58-2 tert-butyl [(3R)-1-{1-(2-chlorobenzyl)-4-iodo-5-[methyl(phenyl)carbamoyl]-1H-imidazol-2-yl}piperidin-3-yl]-carbamate 
• 853068-55-0 ethyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazole-5-carboxylate 
• 1349877-43-5 ethyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-(2-nitrophenyl)-1H-imidazole-5-carboxylate 
• 853069-26-8 tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}-carbamate 
• 853070-04-9 tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate 
• 1349877-49-1 ethyl 2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-1H-imidazole-5-carboxylate 

Relevant academic research and scientific papers

Preparation of 2-aminosubstituted 3H-imidazo[4,5-c]quinolin-4(5H)-ones by palladium-assisted internal biaryl coupling reaction

Representatives of the 3H-imidazo[4,5-c]quinolin-4(5H)-ones have shown interesting biological activity. We have found 2-aminosubstituted 3H-imidazo[4,5-c]quinolin-4(5H)-one as a potent dipeptidyl peptidase 4 inhibitor. However effective synthesis of this

NOVEL CONDENSED IMIDAZOLE DERIVATIVE

Disclosed is a compound represented by the formula (1) below which has a high DPP-IV inhibitory activity and is improved in safety, toxicity and the like. Also disclosed is a prodrug of such a compound and pharmaceutically acceptable salts of them. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like; R2 and R3 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; R4 and R5 independently represent a hydrogen atom, an optionally substituted alkyl group or the like: R6 represents a hydrogen atom, an optionally substituted aryl group or the like; and -Y-NH2, represents a group represented by the following formula (A): (wherein m is 0, 1 or 2; and R7 may not exist or one or two R7 may exist and independently represent an optionally substituted alkyl group or the like) or the like.]