791111-72-3

Basic information

• Product Name: Z-Val-Pro-Val-Pro-Ara-C
• Synonyms: Z-Val-Pro-Val-Pro-Ara-C
• CAS NO: 791111-72-3
• Molecular Weight: 769.852
• Mol File: 791111-72-3.mol

Chemical Properties

• CAS DataBase Reference: Z-Val-Pro-Val-Pro-Ara-C(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Val-Pro-Val-Pro-Ara-C(791111-72-3)
• EPA Substance Registry System: Z-Val-Pro-Val-Pro-Ara-C(791111-72-3)

Safety Data

• Hazardous Substances Data: 791111-72-3(Hazardous Substances Data)

Upstream product

• 791111-79-0 Cbz-Val-Pro-Val-Pro-OH 
• 147-94-4 arabinosyl cytosine 

Relevant articles and documents

PRODRUGS CLEAVABLE BY CD26

The present invention provides a new prodrug technology and new prodrugs in order to increase the solubility, to modulate plasma protein binding or to enhance the biovailability of a drug. In the present invention the prodrugs are conjugates of a therapeutic compound and a peptide (eg tetrapeptide or hexapeptide) wherein the conjugate is cleavable by dipeptidyl-peptidases, more preferably by CD26, also known as DPPIV (dipeptidyl aminodipeptidase IV). The present invention furthermore provides a method of producing said prodrugs, to enhance brain and lymphatic delivery of drugs and/or to extend drug half-lives in plasma.