79123-48-1

Upstream product

• 74-93-1 methylthiol 
• 64573-35-9 2-(1-(4-chlorophenyl)-3,3-bis(methylthio)allylidene)malononitrile 
• 86840-09-7 2-[2-Bromo-1-(4-chloro-phenyl)-3,3-bis-methylsulfanyl-allylidene]-malononitrile 
• 109-77-3 malononitrile 

Downstream Products

• 133615-18-6 4-(4-Chloro-phenyl)-6-methanesulfonyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine 
• 85149-58-2 4-(4-Chloro-phenyl)-2,6-bis-methanesulfonyl-nicotinonitrile 
• 91272-02-5 5-Bromo-4-(4-chloro-phenyl)-2,6-bis-methylsulfanyl-nicotinonitrile 

Relevant academic research and scientific papers

Push-Pull-Butadienes. VI. Synthesis of Substituted Nicotinonitriles

2-Aryl-4,4-bis(methylthio)-1,3-butadiene-1,1-dicarbonitriles 1 react with N-bromo-succinimide or sulphuryl chloride to give 3-bromo- and 3-chlorobutadienedicarbonitriles 3, respectively.Compounds 1 or 3 can be converted with methanethiol in alkaline solut

Push-pull-Butadienes. II. Reactions of 2-Aryl-4,4-bis(methylthio)-1,3-butadiene-1,1-dicarbonitriles with Malononitrile and Ethyl Cyanoacetate

2-Aryl-4,4-bis(methylthio)-1,3-butadiene-1,1-dicarbonitriles 1 react with sodium salts of malononitrile or ethyl cyanoacetate 3 to give 4-aryl-2-methylthio-1,4-pentadiene-1,1,5,5-tetracarbonitriles and ethyl-4-aryl-1,5,5-tricyano-2-methylthio-1,4-pentadienecarboxylates 4, respectively.Also, arylethylidenemalononitriles 5 and bis(methylthio)methylenemalononitrile or ethyl bis(methylthio)methylenecyanoacetate 6 afford 4.Substituted dihydropyridines 8 are prepared by treating 4 with aromatic amines.Compounds 4d, e can be converted to 2-amino-6-aryl-4-methylthiobenzene-1,3-dicarbonitriles 11a, b.