79127-80-3

Basic information

• Product Name: Fenoxycarb
• Synonyms: PRECISION;PRECLUDE;ETHYL 2-(4-PHENOXYPHENOXY)ETHYLAMINOFORMATE;INSEGAR;LEPTOPHOS PESTANAL 250 MG;Ethyl (2-(4-phenoxyphenoxy)ethyl)carbamate;Fenoxycarb;Shuangyangwei
• CAS NO: 79127-80-3
• Molecular Formula: C₁₇H₁₉NO₄
• Molecular Weight: 301.34
• EINECS: 276-696-7
• Product Categories: API intermediates
• Mol File: 79127-80-3.mol

Chemical Properties

• Melting Point: 53-54°C
• Boiling Point: 442.47°C (rough estimate)
• Flash Point: 230.2oC
• Appearance: /
• Density: 1.1222 (rough estimate)
• Vapor Pressure: 1.54E-08mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: 0-6°C
• Water Solubility: 6 mg/L ( at 20℃)
• CAS DataBase Reference: Fenoxycarb(CAS DataBase Reference)
• NIST Chemistry Reference: Fenoxycarb(79127-80-3)
• EPA Substance Registry System: Fenoxycarb(79127-80-3)

Safety Data

• Hazardous Substances Data: 79127-80-3(Hazardous Substances Data)

Usage

Uses

Used in Agriculture:
Fenoxycarb is used as an insect growth regulator for controlling Lepidoptera, scale insects, and suckers on fruit, cotton, olives, vines, and ornamentals. It helps in managing a variety of insect pests, including butterflies, moths, beetles, and sucking insects, thus protecting crops from damage.
Used in Stored Product Protection:
Fenoxycarb is used as a pest control agent for controlling Coleoptera and Lepidoptera in stored products. It is effective against insects that can damage and contaminate stored goods, ensuring the quality and safety of the products.
Used in Public Health:
Fenoxycarb is used as an insect control agent in public health situations to manage cockroaches, fleas, mosquito larvae, and fire ants. Its non-neurotoxic nature makes it a safer option for controlling pests that can pose health risks to humans and animals.
Used in Fire Ant Control:
Fenoxycarb is used as a fire ant bait, helping to control these invasive pests that can cause significant damage to agriculture and pose a threat to human and animal health.
Used in Flea and Mosquito Control:
Fenoxycarb is used for flea and mosquito control, preventing the spread of diseases and providing relief from these annoying insects. It is often formulated as a grit or corncob bait for effective application.

Health Hazard

Fenoxycarb is practically non-toxic to mammals after oral ingestion. The oral LD50 for rats is greater than 10,000 mg/kg and the dermal LD50 for rats is greater than 2,000 mg/ kg. Direct application of fenoxycarb on the skin of laboratory rats caused labored breathing and diarrhea in animals. Although fenoxycarb does not irritate the skin, it is an eye irritant. The liver is the primary organ affected by fenoxycarb in long-term animal studies. Prolonged period of oral exposures to rats and dogs with very low doses of fenoxycarb caused no health effects in the animals, while high concentrations caused adverse effects to the liver of rats, mice, and dogs. Reports on the teratogenicity and mutagenicity of fenoxycarb are not available in the literature.

Metabolic pathway

When the insect larvae of tobacco budworm are fed with 14C-fenoxycarb, at the time of gut purge, the whole of the radio-labeled material is excreted. The main metabolites of fenoxycarb are identified and show hydroxylation of the aromatic rings which makes the excretion easier. Cleavage of the molecule to give carboxylic acid metabolites confirms the hypothesis that the fenoxycarb is not cleaved by esterase.

Degradation

Solutions of [14C-1,4-phenoxy]fenoxycarb in aqueous buffers (pH 3, 7, 9) were maintained at 35 °C for 70 days. The compound was stable over this period (PSD, 1997). In a study to US EPA guidelines, a solution of [14C-1,4-phenoxy]fenoxycarb in sterile buffer at pH 7 and at 25 °C was irradiated with a xenon arc lamp. Light of wavelength less than 290 nm was filtered out. Irradiation was equivalent to one year of average midday sunlight at 40-50°N. Additional tests were done using acetone as a photosensitiser. Samples were analysed using LSC and HPLC methods. Little 14CO2 was evolved and 80 and 40% of the parent fenoxycarb degraded within 210 minutes in the sensitised and unsensitised samples, respectively. Seven photoproducts were identified from the unsensitised samples but only the phenol (2) was formed (see Scheme 1) in appreciable amount (12.3% of applied radioactivity after 6 hours) (PSD, 1997).

InChI:InChI=1/C17H19NO4/c1-2-20-17(19)18-12-13-21-14-8-10-16(11-9-14)22-15-6-4-3-5-7-15/h3-11H,2,12-13H2,1H3,(H,18,19)

Upstream product

• 831-82-3 4-Phenoxyphenol 

Downstream Products

• 389796-15-0 ethyl N-[2-(4-phenoxyphenoxy)ethyl]-N-(5-ethoxycarbonylpentyl)carbamate 
• 389796-10-5 ethyl N-[2-(4-phenoxyphenoxy)ethyl]-N-(5-carboxypentyl)carbamate 
• 96222-11-6 N-ethoxycarbonyl-N-2-(4-phenoxyphenoxy)-ethyl-oxamic acid methyl ester 

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