79128-50-0Relevant academic research and scientific papers
Imidazole derivatives
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, (2008/06/13)
Imidazole derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof are provided: STR1 In the formula, R4 1- or 2-naphthyl, optionally substituted with Cl, Br, or I; 1,2,3,4-tetrahydro-6-naphthyl; 3-duryl, optionally 6-substituted by Cl, Br, I, NO2, CH3 or benzyl; mesityl, phenyl 2-, 3- or 4-substituted by OH, NH2, NO2, CH3 CONH, phenyl, phenoxy, cyclohexyl, phenylthio, benzylthio, C1 -C6 alkyl or C1 C6 alkylthio; 4-bibenzylyl; 3,4-dihydroxyphenyl, n=0, 1 or 2 and (a) R=H, alkyl having 1 to 6 carbon atoms or phenyl R1 =H, alkyl having 1 to 6 carbon atoms or phenyl one of R2 and R3 =H the other of R2 and R3 =H, OH, benzoyloxy, C2 -C7 alkanoyloxy, N-(C1 -C6 alkyl)-carbamoyloxy, N,N-[di-(C1 C6)alkyl]-carbamoyloxy, but if R2 =R3 =H then R=R1 =H, or (b) R=H, C1 -C6 alkyl, phenyl R1 =H, C1 -C6 alkyl, phenyl R2 +R3 =O, or STR2 The compounds of formula I are anti-convulsivants.
Further research on durene derivatives - IV. N-[2,3,5,6-tetramethylbenzoyl)alkyl]imidazoles and N-{[β-(2,3,5,6-tetramethylphenyl)-β-hydroxy]ethyl}imidazoles with anticonvulsant activity
Leonardi,Motta,Subissi,Nardi
, p. 711 - 720 (2007/10/02)
A series of N-[(2,3,5,6-tetramethylbenzoyl)alkyl]imidazoles and of N-{[β-(2,3,5,6-tetramethylphenyl)-β-hydroxy]ethyl}imidazoles has been synthesized. All compounds were tested in mice for anticonvulsant activity against electroshock and pentylenetetrazole
