79135-52-7

Upstream product

• 79135-55-0 1,2-Dichloro-1,2-bis(p-isopropylphenyl)ethane 
• 17356-09-1 4-iodocumene 
• 74-86-2 acetylene 
• 23152-99-0 p-ethynylcumene 
• 54290-22-1 α,α-dimethylbenzyl iodide 
• 586-61-8 4-iso-propylbromobenzene 
• 1010840-17-1 1,2-bis(4’,4’,5’,5’-tetramethyl[1’,3’,2’]dioxaborolan-2’-yl)ethyne 
• 82234-68-2 p-dichloromethylcumene 
• 384850-37-7 1-(4-isopropylphenyl)-2-trimethylsilylacetylene 
• 79152-62-8 C₂₀H₂₆N₄ 

Downstream Products

• 5789-33-3 1,2-bis(4-isopropylphenyl)ethane 
• 79135-61-8 4,4'-diisopropyl-deoxybenzoin 
• 81734-58-9 4,4'-diisopropyl-cis-stilbene 

Relevant academic research and scientific papers

Rh(iii)-Catalyzed three-component cascade annulation to produce theN-oxopropyl chain of isoquinolone derivatives

Developing powerful methods to introduce versatile functional groups at theN-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct theN-oxopropyl chain of isoquinolone derivativesviarhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.

Electrochemistry-Enabled Ir-Catalyzed Vinylic C-H Functionalization

Synergistic use of electrochemistry and organometallic catalysis has emerged as a powerful tool for site-selective C-H functionalization, yet this type of transformation has thus far mainly been limited to arene C-H functionalization. Herein, we report the development of electrochemical vinylic C-H functionalization of acrylic acids with alkynes. In this reaction an iridium catalyst enables C-H/O-H functionalization for alkyne annulation, affording α-pyrones with good to excellent yields in an undivided cell. Preliminary mechanistic studies show that anodic oxidation is crucial for releasing the product and regeneration of an Ir(III) intermediate from a diene-Ir(I) complex, which is a coordinatively saturated, 18-electron complex. Importantly, common chemical oxidants such as Ag(I) or Cu(II) did not give significant amounts of the desired product in the absence of electrical current under otherwise identical conditions.

Calcium carbide catalytically activated with tetra-: N -butyl ammonium fluoride for Sonogashira cross coupling reactions

We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC2 as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over existing methods regarding operational simplicity, use of readily available starting materials, and low cost.

Modular Synthesis of Diarylalkynes and Their Efficient Conversion into Luminescent Tetraarylbutadienes

A series of electronically distinct symmetrical diarylalkynes were prepared via a general Suzuki-Miyaura cross-coupling protocol. These alkynes underwent zirconium-mediated coupling to yield zirconacycles that afford new tetraaryl-1,3-butadienes upon subsequent protonolysis; these butadienes display deep blue or green emission and represent promising building blocks for light-emitting devices. The presented synthetic pathway allows access to new libraries of molecular light emitters with tunable luminescence and considerable thermal- and photostabilities.

5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase

The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.

5,6,7-trisubstituted-4-aminopyrido[2,3-D] pyrimidine compounds

A compound having the formula wherein R1, R2, R3, R4 and R5 are defined, a method for inhibiting adenosine kinase by administering a compound thereof, a pharmaceutical composition comprising a therapeutically effective amount of a compound thereof above i

NEW SIMPLE METHOD FOR THE SYNTHESIS OF CIS-STILBENES

A new method involving catalytic acetylenic condensation as the key stage was developed for the synthesis of cis-stilbenes.Subsequent selective hydrogenation of the synthesized alkyltolanes over Pd-CaCO3 gave a series of alkyl-substituted stilbenes. 1,8-Dimethylphenanthrene was obtained from o-iodotoluene.

Hydrogenation Reactions of Some Spool-Shaped Acetylenes

The spool-shaped acetylenes bis(p-isopropylphenyl)acetylene (1a) and bis(p-tert-butylphenyl)acetylene (1b) have been synthesized and rigorously characterized.Their hydrogenation reactions have been studied.These acetylenes add hydrogen smoothly in solution, but at low pressures they do not add hydrogen on the metallic catalysts platinum, palladium, and nickel.This anomaly is explained in terms of the postulate that the isopropyl and tertiary butyl groups prevent the CC group from resting flatly upon the catalyst.The simple structure of these molecules provides a crude estimate of the minimum critical distance of approach of the unsaturated moiety of the molecule to the surface of the metallic catalyst for effective hydrogenation.