79139-61-0Relevant academic research and scientific papers
PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS
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Page/Page column 299; 300, (2008/06/13)
Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, X, and n are as defined for Formula (I) in the description, processes for the preparation of the compounds and new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and the use of the compounds in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.
A straightforward and efficiently scaleable synthesis of novel racemic 4-substituted-2,8-diazaspiro[4.5]decan-1-one derivatives
Krafft, Eva A.,Kurt, Anke,Maier, Axel,Thomas, Andrew W.,Zimmerli, Daniel
, p. 3245 - 3252 (2007/10/03)
Novel and straightforward syntheses (3-5 steps, high yields) of racemic diazaspiropiperidine derivatives based on the Michael addition of pipecolate-derived enolates to a range of nitroalkenes have been developed. The reaction has been shown to have a gen
Diaza-spiropiperidine derivatives
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Page/Page column 8, (2010/02/12)
The present invention relates to compounds of formula wherein A—B, R1, R2, R3, R4, and n are as defined herein; and to pharmaceutically acceptable salts thereof. The compounds of formula I may be used in the tre
Diaza-spiropiperidine derivatives
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Page/Page column 10, (2010/02/12)
The present invention relates to compounds of formula wherein A-B is —CH2—CH2—, —CH2—O— or —O—CH2—; X is hydrogen or hydroxy; R1 is aryl, optionally substituted by one or two substituents selected fro
THE SYNTHESIS OF 1-PHENYL-3,8-DIAZASPIRODECANES
Parys, Marc Van,Vandewalle, Maurits
, p. 757 - 766 (2007/10/02)
The synthesis of some substituted 3,8-diazaspirodecanes is described.Two routes starting from 1-benzyl-4-oxo-piperidine have been explored.The title compounds are isosteric to the 1,3,8-triazaspirodecane structure present in important neuroleptic agents.
