79143-47-8Relevant academic research and scientific papers
INDAZOLEPROPIONIC ACID AMIDE COMPOUND
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Page/Page column 40, (2012/02/01)
Disclosed is a compound which is useful in preventing and treating cardiac arrhythmia such as atrial fibrillation. A compound represented by formula (1) or a pharmaceutically acceptable salt of the same. In formula (1), ring X represents benzene or pyridine; R1 represents an optionally substituted alkyl group; R2 represents an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted arylalkyl group or an optionally substituted heterocyclic group-substituted alkyl group; R3, R4, R5, R6, R7, R8 and R9 represent each hydrogen or an alkyl group, provided that R3 and R5 may be bonded to each other to form, together with the carbon atom adjacent thereto, a cycloalkyl group; and m represents 0 or 1.
REACTION OF ACTIVATED AZIRIDINES WITH AMINES
Baranov, S. V.,Mochalin V. B.
, p. 951 - 953 (2007/10/02)
The reactions of 1-alkoxycarbonylaziridines, 1-(phenylaminocarbonyl)aziridine, and 1-arylsulfonylaziridines with ammonia and amines were investigated.It was shown that the opening of the aziridine ring in a number of cases is accompanied by aminolysis of the alkoxycarbonyl group.The dependence of the ratio of ring opening and aminolysis products on the structure of the amines is discussed.
