79159-73-2

Upstream product

• 813-19-4 bis(tri-n-butyltin) 
• 3958-57-4 1-bromomethyl-3-nitrobenzene 
• 3748-99-0 N'-(3-nitrobenzylidene)-4-methylbenzenesulfonohydrazide 
• 688-73-3 tri-n-butyl-tin hydride 

Downstream Products

• 1258961-84-0 2-(2-amino-pyrimidin-4-yl)-1-methyl-3-(3-nitro-benzyl)-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester 
• 499792-32-4 9-chloro-1-methyl-7-(3-nitrobenzyl)-1H-pyrazolo[4,3-b]quinoline 

Relevant academic research and scientific papers

COUMARIN-LIKE CYCLIC COMPOUND AS MEK INHIBITOR AND USE THEREOF

Disclosed are a class of coumarin-like cyclic compounds as MEK inhibitors and pharmaceutical compositions comprising the compounds, and the use of same in the preparation of a drug for treating MEK-related diseases. Particularly disclosed are compounds as shown in formula (I) and pharmaceutically acceptable salts thereof or tautomers thereof.

Preparation method of alkyl tin compound or benzyl tin compound

The invention discloses a preparation method of an alkyl tin compound or a benzyl tin compound. N-tosylhydrazones, tri-n-butyltin hydride and alkali react in an organic solvent to obtain the alkyl tin compound or the benzyl tin compound. The addition of a phase transfer catalyst can effectively promote the reaction. According to the method disclosed by the invention, it is first time that the alkyl tin compound or the benzyl tin compound is directly obtained under the mild condition from N-tosylhydrazones without transition metal, the reaction efficiency is high, the reaction cost is low, and the method has good tolerance and universality on functional groups and can be widely used for preparing the alkyl tin compound or the benzyl tin compound.

Synthesis of Benzyltributylstannanes by the Reaction of N-Tosylhydrazones with Bu3SnH

An efficient stannylation process with N-tosylhydrazones or directly with carbonyl compounds has been developed. A series of functionalized benzyl- and alkyltributylstannanes can be synthesized in moderate to good yields under transition-metal-free conditions. Tandem transformations involving stannylation/Stille cross-coupling reaction have been carried out without purification of the benzyltributylstannane intermediates to afford a series of diarylmethane derivatives.

SUBSTITUTED PYRIMIDINYLPYRROLOPYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

Pyrimidinylpyrrolopyridinone derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the inven

SYNTHESIS OF ORGANOTRIALKYLSTANNANES. THE REACTION BETWEEN ORGANIC HALIDES AND HEXAALKYLDISTANNANES IN THE PRESENCE OF PALLADIUM COMPLEXES

The aryl halides YC6H4X (X=Br or I) have been shown to react with the distannanes (R3Sn)2 (R=n-Bu or Me) in toluene in the presence of or to give the compounds YC6H4SnR3 for (a) R=n-Bu, Y=H, p-OMe, o-Me, p-Me, m-Cl, p-Cl, m-CN, p-COCH3 and m-NO2, and (b) R=Me, Y=H, p-OMe, p-Me, p-CN, p-COCH3, m-NO2 and p-NO2.Benzyl halides YC6H4CH2X (X=Cl or Br) similarly give YC6H4CH2SnR3 for (a) R=n-Bu, Y=H, m-OMe, p-OMe, m-Cl, m-CN, and m-NO2, and (b) R=Me, Y=m-Cl, m-CN, p-CN and m-NO2.These reactions are of special value as preparative procedures in cases in which Grignard or organolithium reagents cannot be used.Allyl chloride and bromide were likewise shown to react with (n-Bu3Sn)2 to give CH2=CHCH2SnBu3, but n-BuCl and n-BuBr gave only a trace of n-Bu4Sn.The mixed dimetallo species n-Bu3SnSiMe3 was shown to react with aryl bromides YC6H4Br (X=H, p-OMe, p-Me, or p-Cl) to give the arylsilicon compounds YC6H4SiMe3, with no aryltin products.