791595-74-9

Usage

Uses

Used in Pharmaceutical Industry:
5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is used as a building block for the synthesis of pharmaceuticals due to its potential as an anti-cancer and anti-inflammatory agent. It is valued for its ability to contribute to the development of new drugs targeting various diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is utilized as a component in the creation of agrochemicals, leveraging its antibacterial and antifungal properties to develop products that protect crops and enhance agricultural yields.
Used in Drug Development:
5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is employed as a key intermediate in drug development, where its unique structure and functional groups facilitate the design and synthesis of novel therapeutic agents with potential applications in treating a range of medical conditions.
Used in Research and Development:
5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is also used in research and development settings to explore its potential applications and to understand its mechanisms of action, thereby contributing to the advancement of scientific knowledge and the creation of innovative solutions in medicine and agriculture.

InChI:InChI=1/C7H6BrN3/c8-4-1-2-5-6(3-4)11-7(9)10-5/h1-3H,(H3,9,10,11)

Upstream product

• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 506-68-3 bromocyane 

Downstream Products

• 191028-25-8 N-(5-bromo-1H-benzo[d]imidazol-2-yl)acetamide 
• 1416335-30-2 N-(6-(5-(2,4-difluorophenylsulfonamido)-6-methoxypyridin-3-yl)-1H-benzo[d]imidazol-2-yl)acetamide 

Relevant academic research and scientific papers

Lewis-acid Promoted Chemoselective Condensation of 2-Aminobenzimidazoles or 3-Aminoindazoles with 3-Ethoxycyclobutanones to Construct Fused Nitrogen heterocycles

A Lewis-acid promoted chemoselective condensation of 2-aminobenzimidazoles or 3-aminoindazoles with 3-ethoxycyclobutanones is presented. Diverse fused heterocycles benzo[4,5]-imidazo[1,2-a]pyrimidine and pyrimido[1,2-b]-indazole derivatives were obtained in moderate to high yields under mild conditions, the reaction mechanism of which was in sharp contrast to previous [3+3] annulation reaction of 3-ethoxycyclobutanones. (Figure presented.).

A facile synthesis of 2-aminobenzoxazoles and 2-aminobenzimidazoles using N -cyano- N -phenyl- P -toluenesulfonamide (NCTS) as an efficient electrophilic cyanating agent

A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine derivatives in the presence of lithium hexamethyldisilazide (LiHMDS) is described. This novel protocol boasts operational simplicity, shorter reaction time, and simple workup.

Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

2-aminobenzimidazole derivatives strongly inhibit and disperse Pseudomonas aeruginosa biofilms

Bacterial biofilms are exceptionally difficult to clear using traditional antibiotics and constitute a significant health threat. 2-Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known. Copyright

BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS

Provided are compounds of Formulas I, II, III, IV, V, and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).

JAK-2 MODULATORS AND METHODS OF USE

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention