791595-74-9

Basic information

• Product Name: 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE
• Synonyms: 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE;2-Amino-5-bromobenzimidazole;2-AMINO-5(6)-BROMO-1H-BENZIMIDAZOLE;2-AMino-5-BroMo-1H-BenziMidazole;5-Bromo-1H-benzo[d]imidazol-2-amine hydrochloride;6-bromo-1H-Benzimidazol-2-amine;6-bromo-1H-benzo[d]imidazol-2-amine;5-Bromo-1H-benzimidazol-2-amine
• CAS NO: 791595-74-9
• Molecular Formula: C₇H₆BrN₃
• Molecular Weight: 212.05
• Product Categories: pharmacetical
• Mol File: 791595-74-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 425.2 °C at 760 mmHg
• Flash Point: 211 °C
• Appearance: /
• Density: 1.867 g/cm³
• Vapor Pressure: 1.94E-07mmHg at 25°C
• Refractive Index: 1.8
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.16±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE(791595-74-9)
• EPA Substance Registry System: 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE(791595-74-9)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 791595-74-9(Hazardous Substances Data)

Usage

General Description

5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is a chemical compound with the molecular formula C7H5BrN4. It is an aromatic amine that contains a benzimidazole ring with a bromine atom attached to the 5th position. 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has been studied for its potential as an anti-cancer and anti-inflammatory agent. Additionally, it has been investigated for its antibacterial and antifungal properties. 5-BROMO-1H-BENZIMIDAZOLE-2-AMINE is a versatile compound with potential applications in the development of new drugs and biologically active molecules.

InChI:InChI=1/C7H6BrN3/c8-4-1-2-5-6(3-4)11-7(9)10-5/h1-3H,(H3,9,10,11)

Upstream product

• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 1575-37-7 4-Bromo-benzene-1,2-diamine 
• 506-68-3 bromocyane 

Downstream Products

• 191028-25-8 N-(5-bromo-1H-benzo[d]imidazol-2-yl)acetamide 
• 1416335-30-2 N-(6-(5-(2,4-difluorophenylsulfonamido)-6-methoxypyridin-3-yl)-1H-benzo[d]imidazol-2-yl)acetamide 

Relevant articles and documents

Lewis-acid Promoted Chemoselective Condensation of 2-Aminobenzimidazoles or 3-Aminoindazoles with 3-Ethoxycyclobutanones to Construct Fused Nitrogen heterocycles

A Lewis-acid promoted chemoselective condensation of 2-aminobenzimidazoles or 3-aminoindazoles with 3-ethoxycyclobutanones is presented. Diverse fused heterocycles benzo[4,5]-imidazo[1,2-a]pyrimidine and pyrimido[1,2-b]-indazole derivatives were obtained in moderate to high yields under mild conditions, the reaction mechanism of which was in sharp contrast to previous [3+3] annulation reaction of 3-ethoxycyclobutanones. (Figure presented.).

Inhibition and Dispersion of Bacterial Biofilms with 2-Aminobenzimidazole Derivatives

Compounds described herein inhibit biofilm formation or disperse pre-formed biofilms of Gram-negative bacteria. Biofilm-inhibitory compounds can be encapsulated or contained in a polymer matrix for controlled release. Coatings, films, multilayer films, hydrogels, microspheres and nanospheres as well as pharmaceutical compositions and disinfecting compositions containing biofilm-inhibitory compounds are also provided. Methods for inhibiting formation of biofilms or dispersing already formed biofilms are provided. Methods for treating infections of gram-negative bacteria which form biofilms, particularly those of Pseudomonas and more particularly P. aeruginosa.

BENZIMIDAZOLE DERIVATIVES AS ANTIVIRAL AGENTS

Provided are compounds of Formulas I, II, III, IV, V, and pharmaceutically acceptable salts thereof, their pharmaceutical compositions, their methods of preparation, and their use for treating viral infections mediated by a member of the Flaviviridae family of viruses such as hepatitis C virus (HCV).