791613-42-8

Basic information

• Product Name: (1S,3R,4R)-3-(4',5'-dihydro-5',5'-diphenyl-1',3'-oxazol-2'-yl)-2-azabicyclo[2.2.1]heptane
• Synonyms: (1S,3R,4R)-3-(4',5'-dihydro-5',5'-diphenyl-1',3'-oxazol-2'-yl)-2-azabicyclo[2.2.1]heptane
• CAS NO: 791613-42-8
• Molecular Weight: 318.418
• Mol File: 791613-42-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (1S,3R,4R)-3-(4',5'-dihydro-5',5'-diphenyl-1',3'-oxazol-2'-yl)-2-azabicyclo[2.2.1]heptane(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3R,4R)-3-(4',5'-dihydro-5',5'-diphenyl-1',3'-oxazol-2'-yl)-2-azabicyclo[2.2.1]heptane(791613-42-8)
• EPA Substance Registry System: (1S,3R,4R)-3-(4',5'-dihydro-5',5'-diphenyl-1',3'-oxazol-2'-yl)-2-azabicyclo[2.2.1]heptane(791613-42-8)

Safety Data

• Hazardous Substances Data: 791613-42-8(Hazardous Substances Data)

Upstream product

• 791613-41-7 (1S,3R,4R)-3-(4',5'-dihydro-5',5'-diphenyl-1',3'-oxazol-2'-yl)-2-azabicyclo[2.2.1]heptane-2-N-carboxylic acid p-nitrobenzyl ester 
• 18903-44-1 2-amino-2,2-diphenylethan-1-ol 
• 700867-39-6 (1S,3S,4R)-2-aza-bicyclo-[2.2.1]-heptane-2,3-dicarboxylic acid 2-p-nitrobenzyl ester 
• 791613-40-6 (1S,3R,4R)-3-(2'-hydroxy-1',1'-diphenylethylcarbamoyl)-2-azabicyclo[2.2.1]heptane-2-N-carboxylic acid p-nitrobenzyl ester 
• 171754-03-3 (1S,3R,4R)-2-aza-bicyclo-[2.2.1]-heptane-3-carboxylic acid 

Relevant articles and documents

Extending the substrate scope of bicyclic p-oxazoline/thiazole ligands for ir-catalyzed hydrogenation of unfunctionalized olefins by introducing a biaryl phosphoroamidite group

This study identifies a series of Ir-bicyclic phosphoroamidite-oxazoline/thiazole catalytic systems that can hydrogenate a wide range of minimally functionalized olefins (including E- and Z-tri- and disubstituted substrates, vinylsilanes, enol phosphinates, tri- and disubstituted alkenylboronic esters, and ?±,?2-unsaturated enones) in high enantioselectivities (ee values up to 99%) and conversions. The design of the new phosphoroamidite-oxazoline/thiazole ligands derives from a previous successful generation of bicyclic N-phosphane-oxazoline/thiazole ligands, by replacing the N-phosphane group with a p-acceptor biaryl phosphoroamidite moiety. A small but structurally important family of Ir-phosphoroamidite-oxazoline/thiazole precatalysts has thus been synthesized by changing the nature of the Ndonor group (either oxazoline or thiazole) and the configuration at the biaryl phosphoroamidite moiety. The substitution of the N-phosphane by a phosphoroamidite group in the bicyclic N-phosphane-oxazoline/thiazole ligands extended the range of olefins that can be successfully hydrogenated.