791796-85-5Relevant academic research and scientific papers
Photochemically induced synthesis of the topoisomerase i inhibitors indeno [1,2-c]isoquinoline-5,11-diones
Dubois, Mélanie,Deniau, Eric,Couture, Axel,Grandclaudon, Pierre
, p. 1047 - 1051 (2012)
A convenient synthesis of indeno[1,2-c]isoquinoline-5,11-diones has been achieved using combinational photochemical and carbocationic cyclization tactics. The synthetic route involved first the construction of adequately functionalized N-styryl benzamides via Suzuki-Miyaura cross-coupling reaction with enol phosphate combined with a six - electron photocyclization process. The assembling of the title compounds was readily ensured through sequential carbocationic annulation reaction and ultimate oxidation of a latent hydroxy functionality. Georg Thieme Verlag Stuttgart · New York.
