791807-33-5

Upstream product

• 609-02-9 methyl-malonic acid dimethylester 
• 63909-29-5 (E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene 

Downstream Products

• 347850-51-5 Methyl 3-((1R)-1-hydroxyethyl)(3S,4S)-4-(3-hydroxy-4-methoxyphenyl)-3-methylpyrrolidinecarboxylate 
• 884846-87-1 1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-3-yl)ethanone 
• 884846-88-2 (R)-1-((3S,4S)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methylpyrrolidin-3-yl)ethan-1-ol 
• 791807-34-6 (3S,4S)-methyl 4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-2-oxopyrrolidine-3-carboxylate 
• 884846-90-6 1-((3S,4S)-4-(3-hydroxy-4-methoxyphenyl)-3-((R)-1-hydroxyethyl)-3-methyl-pyrrolidin-1-yl)-2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethanone 
• 884846-89-3 1-((3S,4S)-3-((R)-1-hydroxyethyl)-4-(3-(benzyloxy)-4-methoxyphenyl)-3-methyl-pyrrolidin-1-yl)-2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethanone 

Relevant academic research and scientific papers

Preparation of pyrrolidine-based PDE4 inhibitors via enantioselective conjugate addition of α-substituted malonates to aromatic nitroalkenes

The enantioselective conjugate addition of α-substituted malonates to aromatic nitroalkenes generates a stereocenter at the carbon bearing the aromatic group and an adjacent prochiral center from the α-substituted malonate. Nitro reduction followed by dia