791823-92-2Relevant academic research and scientific papers
Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: A potential multitarget vaccine against respiratory infections
Bay, Sylvie,Huteau, Valérie,Zarantonelli, Maria-Leticia,Pires, René,Ughetto-Monfrin, Jo?l,Taha, Muhamed-Kheir,England, Patrick,Lafaye, Pierre
, p. 3916 - 3919 (2004)
Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc-ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.
