791845-23-3Relevant academic research and scientific papers
Synthesis and biological evaluation of fluorescent leishmanicidal analogues of hexadecylphosphocholine (Miltefosine) as probes of antiparasite mechanisms
Saugar, José M.,Delgado, Javier,Hornillos, Valentín,Luque-Ortega, Juan R.,Amat-Guerri, Francisco,Acu?a, A. Ulises,Rivas, Luis
, p. 5994 - 6003 (2008/04/05)
The leishmanicidal mechanism of miltefosine (hexadecylphosphocholine, MT) is not clearly understood. Valuable insights into its mode of action could be obtained by fluorescence techniques, given suitably emitting analogues. In this regard, the synthesis a
Fluorescent phenylpolyene analogues of the ether phospholipid edelfosine for the selective labeling of cancer cells
Quesada, Ernesto,Delgado, Javier,Gajate, Consuelo,Mollinedo, Faustino,Acu?a, A. Ulises,Amat-Guerri, Francisco
, p. 5333 - 5335 (2007/10/03)
Edelfosine (ET-18-OCH3), a synthetic antitumor ether lipid, is taken up by malignant but not by normal cells, triggering apoptosis in a large variety of human tumor cells. The synthesis of the first fluorescent edelfosine analogue (6), with apo
