79185-36-7Relevant academic research and scientific papers
ALLOSTERIC PROTEIN KINASE MODULATORS
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Page/Page column 63, (2012/03/10)
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
ALLOSTERIC PROTEIN KINASE MODULATORS
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Page/Page column 130, (2010/04/30)
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
3,5-Diphenylpent-2-enoic acids as allosteric activators of the protein kinase PDK1: Structure-activity relationships and thermodynamic characterization of binding as paradigms for PIF-binding pocket-targeting compounds
Stroba, Adriana,Schaeffer, Francis,Hindie, Valerie,Lopez-Garcia, Laura,Adrian, Iris,Fr?hner, Wolfgang,Hartmann, Rolf W.,Biondi, Ricardo M.,Engel, Matthias
supporting information; experimental part, p. 4683 - 4693 (2010/02/28)
The modulation of protein kinase activities by low molecular weight compounds is a major goal of current pharmaceutical developments. In this line, important efforts are directed to the development of drugs targeting the conserved ATP binding site. Howeve
