79203-48-8

Usage

Uses

Used in Pharmaceutical Industry:
(5alpha,7alpha,13alpha,17alpha)-17-(furan-3-yl)-7-hydroxy-4,4,8-trimethylandrosta-1,14-dien-3-one is used as a potential therapeutic agent for various applications due to its steroid structure and the presence of a furan ring and hydroxyl group. These structural features may confer anti-inflammatory, immunomodulatory, or hormonal activities, making it a promising candidate for further study in drug design and development.
Used in Drug Design and Development:
In the field of drug design and development, (5alpha,7alpha,13alpha,17alpha)-17-(furan-3-yl)-7-hydroxy-4,4,8-trimethylandrosta-1,14-dien-3-one is used as a starting point for the creation of novel compounds with potential applications in treating various diseases and conditions. The unique properties of the furan ring and hydroxyl group, in combination with the steroid backbone, may lead to the discovery of new drugs with improved efficacy and reduced side effects.

Upstream product

• 25279-67-8 azadirone 
• 25279-67-8 azadirone 

Downstream Products

• 25279-67-8 azadirone 
• 86558-70-5 (8R,10S,13S,17R)-17-Furan-3-yl-4,4,8,10,13-pentamethyl-5,6,8,9,10,11,12,13,16,17-decahydro-4H-cyclopenta[a]phenanthrene-3,7-dione 
• 25279-67-8 azadirone 

Relevant academic research and scientific papers

Complete assignments of the 1H and 13C NMR spectra of 15 limonoids

Unambiguous and complete assignments of 1H and 13C NMR chemical shifts for 15 limonoids, eight of them found in natural sources and seven other synthetic derivatives, are presented. The assignments are based on 2D shift-correlated [

Biological investigation and structure-activity relationship studies on azadirone from Azadirachta indica A. Juss

Azadirone 1, a limonoidal constituent of Azadirachta indica is found to possess potent cytotoxic activity against a panel of human cancer cell lines in our in vitro studies. In vitro screening of a number of semi-synthetic analogues of 1 revealed that the α,β-unsaturated enone moiety or its equivalent conjugated system in A-ring, C-7 acetyloxy/chloroacetyloxy or keto group in B-ring and the furan moiety are responsible for the activity of 1 and its analogues. Compound 1 and two of the semi-synthetic analogues 10 and 13 were found to possess good in vivo antitumor activity in modified hollow fiber animal models.

A Correlation of Azadirone with Cedrelone

Azadirone (I) has been hydrolysed and the resulting alcohol (VIII) oxidised to a 7-keto compound (IX) which on Barton oxidation yields 1,2-epoxycedrelone (XIII), cedrelone (VII) and two carboxylic acids (XIV) and (XV) derived by a benzilic acid rearrangement.Thus the neem limonoids have been correlated with cedrelone.