79205-19-9

Upstream product

• 1989-53-3 2,6-dimethoxybenzoyl chloride 
• 40167-34-8 methyl 4-phenyl-1H-pyrrole-3-carboxylate 
• 79205-17-7 methyl 5-(2',6'-dimethoxybenzoyl)-4-phenylpyrrole-3-carboxylate 

Downstream Products

• 79205-20-2 2-(2',6'-dimethoxybenzoyl)-3-phenylpyrrole 
• 79205-22-4 2-(2',6'-dihydroxybenzoyl)-3-phenylpyrrole 

Relevant academic research and scientific papers

Pyoluteorin Derivatives. II. Synthetic Approaches to Pyrrole Ring Substituted Pyoluteorins (1)

A method for the regiospecific synthesis of 3-substituted 2-aroylpyrroles is described.These pyrroles, which are structurally related to the naturally occuring antibiotic pyoluteorin, are prepared by a Friedel-Crafts aroylation of 4-substituted pyrrole-3-carboxylic acid esters with 2,6-dimethoxybenzoyl chloride.The carboalkoxy group is then removed by hydrolysis and decarboxylation to produce isomerically pure 3-substituted-2-(2',6'-dimethoxybenzoyl)pyrroles (5 and 13).Conversion of these pyrroles into pyoluteorin-like coumpounds led to some unexpected products which arise from facile cleavage of the dihydroxybenzoyl portion of the molecules during chlorination.