79221-04-8Relevant academic research and scientific papers
Tandem insertion-cyclization reaction of isocyanides in the synthesis of 1,4-diaryl-1H-imidazoles: Presence of N-arylformimidate intermediate
Pooi, Benjamin,Lee, Jeongbin,Choi, Kyujin,Hirao, Hajime,Hong, Soon Hyeok
, p. 9231 - 9245 (2014/12/11)
A straightforward and high-yielding synthesis of 1,4-diaryl-1H-imidazoles is reported. 1,4-Diaryl-1H-imidazoles have been difficult to access in ambient conditions, but our method utilizes two different facets of isocyanide reactivity to achieve it. The r
PIPERAZINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLU5 RECEPTORS
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Page/Page column 32-33, (2013/07/05)
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurologic
NOVEL COMPOUNDS
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Paragraph 0148; 0150, (2013/06/28)
This invention relates to compounds of formula I their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurologic
Thermal rearrangements of tetrahydroimidazo[1,5-b]isoxazole-2,3-dicarboxylates. Synthesis of 3H-imidazol-1-ium ylides and their silver derivatives
Co?kun, Necdet,?etin, Meliha
experimental part, p. 2053 - 2060 (2010/04/26)
Isoxazolines 2 from the cycloaddition of imidazoline 3-oxides 1 with DMAD undergo rearrangement to 3,4-dihydro-2H-imidazol-1-ium-1-(1,2-bis-methoxycarbonyl-2-oxo-ethanides) 3, which spontaneously undergo elimination to give 3H-imidazol-1-ium-1-(1,2-bis-me
Synthesis of 4-oxo-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-3-carboxylic acid esters
Coskun, Necdet,Yilmaz, Bilai
, p. 1617 - 1623 (2007/10/03)
3-Imidazoline 3-oxides react regioselectively with 3-phenylpropanoic acid alkyl esters to give the corresponding 2-phenyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazole-3-carboxylic acid alkyl esters. This adducts convert to imidazole and the corresponding al
Unusual methylene transfer in reactions of Simmons-Smith reagent with 1,3-diazabuta-1,3-dienes: Synthesis of functionalised imidazole derivatives
Jayakumar,Mahajan, Mohinder P
, p. 2899 - 2904 (2007/10/03)
The reactions of Simmons-Smith reagent with 1-aryl-2-phenyl-4-methylthio-4-secondary amino 1,3-diazabuta-1,3-dienes 1 underwent an unusual 1,4-methylene transfer resulting in the formation of 1-aryl-2-phenyl-4-secondary amino imidazoles 4. Whereas, its re
Synthesis of di- and cis-triaryl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles and their ring-opening reactions
Co?kun, Necdet,Tirli Tat, Fatma,?zel Güven, ?zden
, p. 3413 - 3417 (2007/10/03)
The Δ3-imidazoline 3-oxides 1 undergo diastereoselective cycloaddition with dimethyl acetylenedicarboxylate 2 to give 3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles 3. Thermally and base induced ring-opening reactions of compounds 3 were demonstra
The first examples of di- and cis triaryl-3a,4,5,6- tetrahydroimidazo[1,5-b]isoxazoles and their ring-opening reactions
Co?kun, Necdet,Tirli Tat, Fatma,Güven, ?zden ?zel,ülkü, Din?er,Arici, Cengiz
, p. 5407 - 5409 (2007/10/03)
The Δ3-imidazoline 3-oxides 1 undergo diastereoselective cycloaddition with dimethyl acetylenedicarboxylate 2 to give 3a,4,5,6- tetrahydroimidazo[1,5-b]isoxazoles 3. Thermal and base induced ring-opening reactions of compounds 3 were demonstrat
Regio and diastereoselective addition of imidazoline 3-oxides to aryl isocyanates
Coskun, Necdet
, p. 13873 - 13882 (2007/10/03)
Δ3-Imidazoline 3-oxides 1 underwent regio and diastereoselective cycloaddition with aryl isocyanates 2 to give 5,6,7,7a-tetrahydroimidazo[1,5-b][1,2,4]oxadiazol-2(1H)-ones 3 in excellent yields. Thermally and chemically induced retro cycloaddit
