79242-57-2Relevant academic research and scientific papers
Novel Tetracyclic Spiropiperidines. II. Synthesis of 2-Aryl-2,3-dihydrospiro
Ong, Helen H.,Agnew, Marc N.
, p. 815 - 820 (2007/10/02)
A series of 2-aryl-2,3-dihydrospiro has been synthesized as potential psychotropic agents via an efficient intramolecular fluorine displacement reaction.Treatment of a key intermediate, 4-cyano-4-(2-fluorophenyl)-1-methylpiperidine (2), with a large excess of phenylmagnesium bromide in refluxing tetrahydrofuran led to some 2-arylspiro derivatives, 10 and 11, whose structures are elucidated on the basis of chemical and spectral evidence.
