79243-76-8Relevant academic research and scientific papers
17α-Alkynyl-11β,17-dihydroxyandrostane derivatives: A new class of potent glucocorticoids
Deraedt, R.,Benzoni, J.,Fortin, M.,Philibert, D.
, p. 651 - 666 (2007/10/02)
Replacement of the characteristic dihydroxyacetone side chain of corticoids by a 17α-alkynyl-17β-hydroxy moiety was investigated.It was found that, in particular, the 17α-propynyl substitution is favorable for high local anti-inflammatory activity with reduced systemic effects.Moreover, these compounds were found to be devoid of any affinity for the aldosterone receptor, and may thus be considered as pure glucocorticoids.
