79249-40-4

Upstream product

• 50916-16-0 N-(3-methylphenyl)-2-phenylacetamide 
• 578-46-1 5-methyl-2-nitroaniline 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 206561-54-8 (S)-2-(4-{[3-(2,2-Dimethyl-propionylamino)-2-phenyl-quinoxalin-6-ylmethyl]-amino}-benzoylamino)-pentanedioic acid diethyl ester 
• 206561-52-6 (S)-2-{4-[(3-Chloro-2-phenyl-quinoxalin-6-ylmethyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester 
• 206561-41-3 2,2-Dimethyl-N-(3-phenyl-7-{[prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-quinoxalin-2-yl)-propionamide 
• 206561-43-5 2,2-Dimethyl-N-{3-phenyl-7-[(3,4,5-trimethoxy-phenylamino)-methyl]-quinoxalin-2-yl}-propionamide 
• 206561-47-9 4-{[3-(2,2-Dimethyl-propionylamino)-2-phenyl-quinoxalin-6-ylmethyl]-amino}-benzoic acid ethyl ester 
• 206561-61-7 N-(7-Bromomethyl-3-phenyl-quinoxalin-2-yl)-2,2-dimethyl-propionamide 
• 206561-63-9 2,2-Dimethyl-N-(7-methyl-3-phenyl-quinoxalin-2-yl)-propionamide 
• 206561-60-6 6-Bromomethyl-3-chloro-2-phenyl-quinoxaline 
• 206561-62-8 2-amino-7-methyl-3-phenylquinoxaline 

Relevant academic research and scientific papers

A containing methyl pyrazine structure of the hydrazone compound and its preparation method and application (by machine translation)

The invention discloses a containing methyl pyrazine structure of the hydrazone compound and its preparation method and application. It to 5 - methyl O-nitroaniline and hydrazine hydrate to obtain compound 1; compound 1 with the role of the BMF prepared compound 2; compound 2 by the reaction of the compound with phosphorus oxychloride 3; compound 3 is obtained by the reaction with hydrazine hydrate compound 4; compound 4 with the substituted aldehyde compound by the reaction of the compound (I). Its raw material is simple and easy, simple preparation method, after treatment is convenient, high product yield, but the compound is has herbicidal activity, in particular against bentgrasses, has certain herbicidal effect, to provide the basis for a new pesticide research. (by machine translation)

A containing methyl pyrazine structure of hydrazone compounds as fungicides (by machine translation)

The invention discloses a containing methyl pyrazine structure of hydrazone compounds as fungicides. It to 4 - methyl O-nitroaniline and hydrazine hydrate to obtain compound 1; compound 1 with the role of the BMF prepared compound 2; compound 2 by the reaction of the compound with phosphorus oxychloride 3; compound 3 is obtained by the reaction with hydrazine hydrate compound 4; compound 4 with the substituted aldehyde compound by the reaction of the compound (I). Its raw material is simple and easy, simple preparation method, after treatment is convenient, high product yield, but the compound as having anti-fungal activity, in particular against anthrax sharp spore, strawberry anthrax bacteria and Fructus Lycii (wolfberry fruit) anthrax has good sterilization effect, to provide the basis for a new pesticide research. (by machine translation)

A pyrazine structure containing methyl 1, 2, 4 - triazole derivative and its preparation method and application (by machine translation)

The invention discloses a pyrazine structure containing methyl 1, 2, 4 - triazole derivative and its preparation method and application. For 4 - methyl O-nitroaniline with hydrazine hydrate to produce compound (II). With the MBF reaction, to obtain the product (III). The compound (III) POCl for3 To obtain the product (IV) chloride. Compound (IV) with hydrazine hydrate and offer to obtain the intermediate product (V). Compound (V) in order to POCl3 As the solvent, with the substituted acid compound the response results in the type (I) shown in methyl pyrazine structure containing 1, 2, 4 - triazole derivatives; its raw material is simple and easy, simple preparation method, after treatment is convenient, high product yield, but the compound is has herbicidal activity, in particular against bentgrasses have good herbicidal effect, to provide the basis for a new pesticide research. (by machine translation)

Quinoxaline chemistry. Part 6. Synthesis and evaluation of antiulcer and gastroprotective activity of 2-[arylmethylmercapto-,arylmethylsulfinyl-,piperazinyl-3-R-substituted ]quinoxalines

Thirty compounds possessing quinoxaline structure bearing either substituted arylmethylmercapto-, arylmethylsulfinyl group or a piperazinyl moiety in position 2 were prepared in order to evaluate an antiulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole and ranitidine at the dose of 100 mg/kg after oral administration. Among the compounds of the first group one third showed a moderate activity being about half potent as omeprazole whereas in the second group compound 5b exhibited an activity superior to that of ranitidine accompanied with the lowest incidence of lesions and mortality and another compound (5i) was equiactive as ranitidine.

A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 8. Conversion of Anilides into 3-Substituted Quinolines and into Quinoxalines

Anilides (4) (ArNHCOCH2R) are readily converted into 2-chloro-3-R-quinolines (5) under Vilsmeier conditions and the 3-chloro-group may be removed with zinc and acetic acid yielding 3-substituted quinolines (7).When N-nitrosodialkylamines are used in place of dimethylformamide as the Vilsmeier agent, the anilides are converted into 2-chloroquinoxalines in low yields.Several by-products are formed and the mechanisms have been explored.Thus, the formation of ethyl N-arylcarbamate from the corresponding propionanilide is shown to involve an C->O alkyl migration related to a Wolff rearrangement, while N-arylformimidoyl dichloride (18), nitriles, and isocyanides are derived from C-C cleavage of the substituted side-chain.Variation of the acid chloride component of the Vilsmeier reagent or of the solvent was generally unproductive though use of phosphoryl bromide instead of the chloride caused conversion of anilides into bromoquinolines in low yields.