792892-62-7

Basic information

• Product Name: C₁₁H₁₄N₂S
• CAS NO: 792892-62-7
• Molecular Weight: 206.312
• Mol File: 792892-62-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₁H₁₄N₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₁H₁₄N₂S(792892-62-7)
• EPA Substance Registry System: C₁₁H₁₄N₂S(792892-62-7)

Safety Data

• Hazardous Substances Data: 792892-62-7(Hazardous Substances Data)

Upstream product

• 10282-30-1 4-pyrrolidin-1-yl-benzonitrile 

Downstream Products

• 1189352-79-1 2-(4-pyrrolidin-1-ylphenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ol 
• 1189166-10-6 C₂₁H₂₇N₃O₃S 

Relevant articles and documents

2-Aryl-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols as a class of antitumor agents selectively active in securin-/- cells

A series of 2-(4-aminophenyl)-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ols have been developed as antitumor agents that showed high selectivity against aneuploid cell lines (vs diploid cell lines). Structure-activity relationship studies showed that a hydroxymethyl group at the 2-position of the phenyl ring increased potency and selectivity. A pyrrolidinyl group at the 4-position of the phenyl ring was comparable to a dimethylamino group. The corresponding 5-aza analogs, 2-(4-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ols, retained potency and high level of selectivity against aneuploid cell growth (vs diploid cells). These 5-aza compounds exhibited higher water solubility and higher metabolic stability than the corresponding carba analogs. Compound 19 showed the highest potency against MCF-7 and MDA-MB-361 lines and was selected for further evaluation.