792903-34-5Relevant academic research and scientific papers
Intramolecular Mannich reaction of 2-oxotryptamine and homologues with oxo reagents yielding spiro compounds. Part II
Doernyei, Gabor,Incze, Maria,Kajtar-Peredy, Maria,Szantay, Csaba
, p. 1669 - 1680 (2002)
2-Oxotryptamine and its homo derivative undergo intramolecular Mannich-type cyclization with acetone and other ketones to give spiro[indole-3,3′-pyrrolidin]-2-ones and spiro[indole-3,3′-piperidin]-2-ones. A similar reaction with the bis-homologue of 2-oxotryptamine to yield spiro[azepane-3,3′-indol]-2′-ones was unsuccessful.
