792911-68-3Relevant academic research and scientific papers
Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor
Subramanyam, Chakrapani,Duplantier, Allen J.,Dombroski, Mark A.,Chang, Shang-Poa,Gabel, Christopher A.,Whitney-Pickett, Carrie,Perregaux, David G.,Labasi, Jeff M.,Yoon, Kwansik,Shepard, Richard M.,Fisher, Michael
, p. 5475 - 5479 (2011/10/12)
The discovery, of a series of 2-Cl-5-heteroaryl-benzamide antagonists of the P2X7 receptor via parallel medicinal chemistry is described. Initial analogs suffered from poor metabolic stability and low Vdss. Multi parametric optimizat
BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR
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Page 77, (2008/06/13)
The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I), wherein R1 -R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, incl
