792912-14-2

Basic information

• Product Name: C₂₁H₂₅ClN₂O₂
• Synonyms: C₂₁H₂₅ClN₂O₂
• CAS NO: 792912-14-2
• Molecular Weight: 372.895
• Mol File: 792912-14-2.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₅ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₅ClN₂O₂(792912-14-2)
• EPA Substance Registry System: C₂₁H₂₅ClN₂O₂(792912-14-2)

Safety Data

• Hazardous Substances Data: 792912-14-2(Hazardous Substances Data)

Upstream product

• 1227807-67-1 C₂₁H₃₁BClNO₄ 
• 625470-33-9 methyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1333869-47-8 C₁₄H₁₂ClNO₂ 
• 45732-95-4 1-(aminomethyl)cycloheptanol 
• 1352006-97-3 C₁₃H₁₀ClNO₂ 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 251085-87-7 methyl 5-bromo-2-chloro-benzoate 

Relevant articles and documents

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor

The discovery, of a series of 2-Cl-5-heteroaryl-benzamide antagonists of the P2X7 receptor via parallel medicinal chemistry is described. Initial analogs suffered from poor metabolic stability and low Vdss. Multi parametric optimizat

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

Focused SAR studies were carried out around 5-heteroaryl and 1-amide portions of the 2-chlorobenzamide scaffold, resulting in the discovery of a potent, metabolically stable and centrally penetrable antagonist against P2X7 receptor.