792936-57-3

Upstream product

• 792936-55-1 (3-fluoro-4-methoxy-5-nitro-benzyl)-phosphonic acid diethyl ester 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 320-70-7 3-fluoro-4-methoxy-5-nitro-benzaldehyde 
• 792936-51-7 (3-fluoro-4-methoxy-5-nitro-phenyl)methanol 
• 351-54-2 3-fluoro-p-anisaldehyde 
• 792936-53-9 1-(bromomethyl)-3-fluoro-4-methoxy-5-nitro-benzene 

Downstream Products

• 792936-58-4 4-(3-fluoro-4-hydroxy-5-nitro-benzylidene)-piperidine-1-carboxylic acid tert-butyl ester 
• 792936-59-5 4-(3-amino-5-fluoro-4-hydroxy-benzyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors

Investigation of halogen substitution in lead compound 1 has led to the identification of analogues which combine high affinity for 5-HT1A receptors and potent serotonin reuptake inhibitory activity. Several compounds show an improved selectivity over 5-HT1B and 5-HT1D receptors and a superior pharmacokinetic profile in the rat.

BENZOXAZINONE DERIVATIVES, THEIR PREPARATION AND USE

Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein R1 is hydrogen or C1-6alkyl; and R2 is fluoro or chloro. Methods of preparation and uses thereof in treatment of CNS disorders, such as depression or