79294-58-9

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General Description

4-Hexyloxy-3-Methoxy-Benzoic Acid is an organic compound with the molecular formula C16H22O4. It is a derivative of benzoic acid and contains a hexyloxy and a methoxy group attached to the benzene ring. 4-HEXYLOXY-3-METHOXY-BENZOIC ACID is often used in the synthesis of various pharmaceutical and industrial products. It has been studied for its potential anti-inflammatory and antioxidant properties, making it a candidate for the development of new drugs. Additionally, it has also been investigated for its applications in the field of organic electronics, particularly in the development of organic semiconductors and materials for light-emitting diodes. Overall, 4-Hexyloxy-3-Methoxy-Benzoic Acid has a diverse range of potential applications in various industries and continues to be the subject of ongoing research and development.

InChI:InChI=1/C14H20O4/c1-3-4-5-6-9-18-12-8-7-11(14(15)16)10-13(12)17-2/h7-8,10H,3-6,9H2,1-2H3,(H,15,16)/p-1

Upstream product

• 111-25-1 1-bromo-hexane 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 1026034-31-0 4-Hexyloxy-3-methoxy-benzoic acid methyl ester 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 904688-50-2 4-hexyloxy-3-methoxybenzoic acid ethyl ester 

Relevant academic research and scientific papers

NORVALINE DERIVATIVE AND METHOD FOR PREPARATION THEREOF

Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of said compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2). [wherein X is -CH2-, -O-, -S- or single bond; Ar is optionally substituted aryl or lower cycloalkyl; n is 0 to 2; R1 and R2 are (i) each is hydrogen or lower alkyl; (ii) R1 and R2 are combined to form lower alkylene; or (iii) R1 is hydrogen or lower alkyl and R2 is combined with R4 or R6 to form lower alkylene; R3 and R4 are (i) each is hydrogen or lower alkyl; (ii) R3 and R4 are combined to form lower alkylene; or (iii) R3 is hydrogen or lower alkyl and R4 is combined with R2 or R6 to form lower alkylene; R is or -OR7; R 5 and R6 are (i) each is optionally substituted lower alkyl, or hydrogen; (ii) R5 and R6 are combined to form aliphatic 5- to 6-membered heterocyclic group; or (iii) R5 is optionally substituted lower alkyl or hydrogen and R6 is combined with R2 or R4 to form lower alkylene; R7 is lower alkyl.

Development of a Novel Series of Trialkoxyaryl Derivatives as Specific and Competitive Antagonists of Platelet Activating Factor

The synthesis and structure-activity relationship (SAR) analysis of a novel series of trialkoxyaryl derivatives as specific and competetive inhibitors of platelet activating factor (PAF), are described.Molecular modeling comparisons of PAF with the known antagonists Ginkgolide B and L-652731 led to the selection of N-ethyl>-N,N,N-trimethylammonium iodide (1) from the Wellcome registry of compounds and to the synthesis of the lead compound N-oxy>ethyl>-N,N,N-trimethylammonium iodide (3, pKb 5.43).Furth er SAR considerations directed the design to 2-(hexyloxy)-1,3-dimethoxy-5-benzene (38) (pKb 7.14), a novel, specific, and competitive inhibitor of the PAF receptor in rabbit-washed platelets.

Synthesis and thermal properties of cholesteryl 4-n-alkoxy-3-methoxybenzoates

A homologous series of new liquid crystalline compounds, cholesteryl 4-n-alkoxy-3-methoxybenzoate were synthesized from vanillin and their mesomorphic properties were studied by differential scanning calorimetry, polarizing microscopy and x-ray diffractometry.Each of the homologues from cholesteryl 3,4-dimethoxybenzoate (n=1) to cholesteryl 4-n-hexyloxy-3-methoxybenzoate (n=6) showed a cholesteric-nematic phase (NCh).The other higher homologues (from n=7 to n=18) indicated smectic A (SA) and NCh phases.The temperature region of smectic phases increased with the increase of the chain length of the n-alkoxy group.Transition temperatures in each of the homologues were lower than those in a corresponding non-3-methoxy substituted benzoate ester, due to the destabilizing effect of the lateral methoxy group.The effect was more significant on the homologues having a shorter n-alkoxy chain.It was also found that these esters formed a glassy state by quenching from mesophases and/or the isotropic liquid phase.The change of the glass transition temperature on each homologue (from n=1 to n=6) suggested the effect of the chain length of the n-alkoxyl group on the formation of the glassy state.Keywords: liquid crystals, thermal properties, differential scanning calorimetry, cholesteric phas, smectic A phase, glassy phase.