792949-45-2Relevant academic research and scientific papers
Stereoselective conjugate addition of mixed organoaluminum reagents to α,β-unsaturated N-acyloxazolidinones derived from carbohydrates
Elzner, Stephan,Maas, Steffen,Engel, Stefan,Kunz, Horst
, p. 2153 - 2164 (2004)
The stereoselective synthesis of β-branched carboxylic acid derivatives was accomplished by conjugate addition of mixed organoaluminum reagents to chiral α,β-unsaturated N-acyloxazolidinones. Mixed organoaluminum reagents were generated in situ by transmetalation of Grignard or organolithium compounds with methylaluminum dichloride. Efficient stereocontrol was achieved using different bicyclic glycosamine-derived oxazolidinones, yielding alternatively (R)- or (S)-configured β-branched carboxylic acid derivatives.
