792965-90-3

Basic information

• Product Name: 2(1H)-Pyridinone, 4-[5-(4-methoxyphenyl)-2-oxazolyl]-, hydrazone
• CAS NO: 792965-90-3
• Molecular Formula: C15H14N4O2
• Molecular Weight: 282.302
• Mol File: 792965-90-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyridinone, 4-[5-(4-methoxyphenyl)-2-oxazolyl]-, hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 4-[5-(4-methoxyphenyl)-2-oxazolyl]-, hydrazone(792965-90-3)
• EPA Substance Registry System: 2(1H)-Pyridinone, 4-[5-(4-methoxyphenyl)-2-oxazolyl]-, hydrazone(792965-90-3)

Safety Data

• Hazardous Substances Data: 792965-90-3(Hazardous Substances Data)

Upstream product

• 40513-43-7 2-amino-1-(4-methoxy-phenyl)-ethanone 
• 3883-94-1 2-amino-4'-methoxyacetophenone hydrochloride 
• 6313-54-8 2-chloroisonicotinic acid, 

Relevant articles and documents

Photophysics of a series of efficient fluorescent pH probes for dual-emission-wavelength measurements in aqueous solutions

This paper evaluates the 5-aryl-2-pyridyloxazole backbone to engineer donor-acceptor fluorescent pH probes after one- or two-photon absorption. Parent fluorophores, as well as derivatives that can be used to label biomolecules, can be easily obtained in good yields. These molecules exhibit a large one-photon absorption in the near-UV range, and a strong fluorescence emission that covers the whole visible domain. The 5-aryl-2-pyridyloxazole derivatives also possess significant cross sections for two-photon absorption. Upon pyridine protonation, large shifts were observed in the absorption spectra after one- and two-photon excitation, as well as in the emission spectra. This feature was used to measure the pKa of the investigated compounds that range between 2 and 8. In most of the investigated derivatives, the pKa increased upon light excitation and protonation exchanges took place during the lifetime of the excited state, as shown by phase-modulation fluorometry analysis. Several 5-aryl-2-pyridyloxazole derivatives are suggested as efficient probes to reliably measure the pH of aqueous solutions by means of ratiometric methods that are dependent on fluorescence emission.