79314-57-1Relevant articles and documents
1,3- versus 1,2-Asymmetric Induction in the Reduction of β-Hydroxy Ketones by Intramolecular Hydrosilylation
Anwar, Saeed,Bradley, Gavin,Davis, Anthony P.
, p. 1383 - 1389 (1991)
The role of 1,2-asymmetric induction has been investigated in the 1,3-anti-selective reduction of β-hydroxy ketones via intramolecular hydrosilylation.For the α-methyl β-hydroxy ketones 2a, 3a, the effect of the α-substituent is negligible except that it appears to reinforce 1,3-asymmetric induction.For the α-ethyl β-hydroxy ketones 2b, 3b, 1,3-asymmetric induction is dominant but not overwhelming.The super-acid TfOH2(1+) B(OTf)4(1-) has been used as a catalyst for the hydrosilylation giving, in one case, an improved result when compared with previous methodology.
A two-step chemoenzymatic synthesis of the natural pheromone (+)-sitophilure utilizing isolated, NADPH-dependent ketoreductases
Kalaitzakis, Dimitris,Rozzell, J. David,Kambourakis, Spiros,Smonou, Ioulia
, p. 2309 - 2313 (2007/10/03)
Isolated, NADPH-dependent ketoreductases were used for the synthesis of the aggregation pheromone of the pests rice weevil (Sitophilus oryzae L.) and maize weevil (Sitophilus zeamais M.). This is the easiest and most straight forward synthesis of pheromon
Stereoselective synthesis and cyclisation of the acyclic precursor to auripyrone A and B
Perkins, Michael V.,Sampson, Rebecca A.,Joannou, John,Taylor, Max R.
, p. 3791 - 3795 (2007/10/03)
The acyclic precursor to the auripyrones has been synthesized by a stereoselective aldol strategy. This compound fails to undergo cyclisation to form the spiroacetal dihydropyrone ring system found in auripyrone A and B; instead, it forms a dihydropyrone