79315-03-0Relevant articles and documents
Synthesis and synthetic applications of 1-aryl-2-alkyl-4,5-dihydro-1 H-imidazoles
Reverdito, Ana M.,Perillo, Isabel A.,Salerno, Alejandra
experimental part, p. 2083 - 2097 (2012/06/01)
An easy synthesis of 1-aryl-2-alkyl-4,5-dihydro-1H-imidazoles 1 by cyclo-condensation of N-acyl-N-arylethylenediamines 2 is described. Such precursors were synthesized by aminolysis of the corresponding N-(2-bromoethyl)amides 3. Cyclizations were performed using trimethylsilyl polyphosphate as a mild dehydrating agent, under microwave irradiation. Chemical properties of 1-aryl-2-alkyl-4,5-dihydro-1H-imidazoles, typical of the amidine system, were studied. Reduction of dihydroimidazoles with sodium cyanoborohydride leads regiospecifically to N-alkyl-N-arylethylenediamines 4, and nucleophilic attack to methyl iodide leads to the corresponding 1-aryl-2-alkyl-3-methyl-4,5-dihydro-1H-imidazolium salts 5.
An efficient synthesis of 1-acyl-3-arylimidazolidines catalyzed by montmorillonite K-10 clay under microwave irradiation
Caterina, Maria Cristina,Corona, Maria Veronica,Perillo, Isabel,Salerno, Alejandra
experimental part, p. 771 - 781 (2009/06/18)
The synthesis of 1-acyl-3-arylimidazolidines were performed by reaction of N-acyl-N'-arylethylenediamines with formaldehyde and Montmorillonite clay K-10 as a catalyst under microwave irradiation.