79344-67-5Relevant academic research and scientific papers
Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells
Wilson, Jennifer M.,Henderson, Graham,Black, Fiona,Sutherland, Andrew,Ludwig, Robert L.,Vousden, Karen H.,Robins, David J.
, p. 77 - 86 (2007/10/03)
A family of 5-deazaflavin derivatives has been synthesised using a two-step convergent strategy. The biological activity of these compounds was evaluated in cells, by assessing their ability to stabilize and activate p53. These compounds may act as low molecular weight inhibitors of the E3 activity of HMD2 in tumours that retain wild-type p53. Importantly, we have demonstrated that the nitro group present in all three of the original lead compounds [1-3 (HL198C-E)] is not essential for observation of this biological activity.
INVESTIGATION IN THE ALLOXAZINE AND ISOALLOXAZINE SERIES. LV. SYNTHESIS AND PROPERTIES OF 7-AMINO-SUBSTITUTED ALLOXAZINES
Tul'chinskaya, L. S.,Polyakova, N. A.,Zapesochnaya, L. G.,Karlstedt, N. B.,Gyach, N. V.,et al.
, p. 917 - 923 (2007/10/02)
7-Aminoalloxazine and its derivatives (7-acetylaminoalloxazine and 1,3-dimethyl-7-aminoalloxazine) were synthesized.The introduction of an amino group at position 7 of the alloxazine molecule leads to a substantial decrease in the energy of the long-wave
