79349-23-8

Basic information

• Product Name: 5-(2-HYDROXYPHENYL)-3-METHYL-1,2,4-OXADIAZOLE
• Synonyms: 5-(2-HYDROXYPHENYL)-3-METHYL-1,2,4-OXADIAZOLE;2-(3-methyl-1,2,4-oxadiazol-5-yl)phenol(SALTDATA: FREE)
• CAS NO: 79349-23-8
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 79349-23-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 333.505°C at 760 mmHg
• Flash Point: 155.498°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 5-(2-HYDROXYPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-HYDROXYPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(79349-23-8)
• EPA Substance Registry System: 5-(2-HYDROXYPHENYL)-3-METHYL-1,2,4-OXADIAZOLE(79349-23-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 79349-23-8(Hazardous Substances Data)

Usage

General Description

5-(2-Hydroxyphenyl)-3-methyl-1,2,4-oxadiazole is a chemical compound with the molecular formula C9H8N2O2. It contains a 1,2,4-oxadiazole ring, a 2-hydroxyphenyl group, and a methyl group. 5-(2-HYDROXYPHENYL)-3-METHYL-1,2,4-OXADIAZOLE has potential applications in the field of medicinal chemistry and pharmaceuticals due to its diverse biological activities. It has been studied for its antimicrobial, antiviral, and anticancer properties, and it may have potential as a drug candidate for the treatment of various diseases. Additionally, 5-(2-Hydroxyphenyl)-3-methyl-1,2,4-oxadiazole has been investigated for its photophysical properties and potential use in materials science and organic electronics.

InChI:InChI=1/C9H8N2O2/c1-6-10-9(13-11-6)7-4-2-3-5-8(7)12/h2-5,12H,1H3

Upstream product

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Relevant articles and documents

Absorption and luminescence spectra of 5-aryl-3-methyl-1,2,4-oxadiazoles and their chelate complexes with Zinc(II) and copper(II)

5-(2-Hydroxyphenyl)-3-methyl-1,2,4-oxadiazole and its O-methyl and O-acyl derivatives, as well as zinc(II) and copper(II) chelates, were synthesized. All these compounds showed luminescence with the emission maxima ranging from λ = 332 to 490 nm, but only 5-(2-methoxyphenyl)- and 5-(2-acetoxyphenyl)-3-methyl-1,2,4-oxadiazoles and zinc(II) complex of 5-(2-hydroxyphenyl)-3-methyl-1,2,4-oxadiazole were characterized by high luminescence quantum yield (φ = 0.308–0.452, 0.089–0.153, and 0.115–0.334, respectively). Stable conformers of 5-(2-hydroxyphenyl)-3-methyl-1,2,4-oxadiazole with different structures of the coordination entity were identified by DFT quantum chemical calculations.

SYNTHESIS AND STUDY OF THE STRUCTURE OF o-HYDROXYARYL-1,2,4-OXADIAZOLES

The reaction of 4-oxo-1,3-benz- and naphthoxazinium perchlorates with hydroxylamine leads to 5-(-o-hydroxyaryl)-1,2,4-oxadiazoles rather than to 3-(o-hydroxyaryl)-1,2,4-oxadiazoles, as was previously assumed.The structure of the compounds obtained was pro