79355-50-3

Upstream product

• 108-24-7 acetic anhydride 
• 61377-97-7 (5S,6S)-5-Hydroxy-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester 
• 33279-99-1 4-carbo-t-butoxyoxepin 
• 61377-97-7 (5S,6S)-5-Hydroxy-6-[(1R,3R,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester 
• 5625-52-5 1-methylpiperazin-2,5-dione 
• 79247-68-0 1-Methoxymethyl-4-methyl-piperazine-2,5-dione 
• 61377-97-7 (5S,6S)-5-Hydroxy-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester 
• 61377-97-7 (5RS)-5r-hydroxy-6t-[(1SR)-3ξ-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-1,3-dienecarboxylic acid tert-butyl ester 
• 61377-96-6 (1R,3S,5R)-3-(4-Methoxy-phenyl)-6-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 

Downstream Products

• 67-99-2 dl-Gliotoxin 
• 61378-00-5 (1RS)-6-((1SR)-2-chloromethyl-6t-hydroxy-cyclohexa-2,4-dien-r-yl)-3ξ-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 61378-02-7 7c-hydroxy-4-hydroxymethyl-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione 
• 61378-01-6 4-benzyloxymethyl-7c-hydroxy-2ξ-(4-methoxy-phenyl)-13-methyl-(6ac)-7,11-dihydro-6aH-4r,11ac-azaethano-[1,3,5]dithiazepino[5,4-a]indole-5,12-dione 
• 61377-99-9 (1RS)-6-((1SR)-6t-acetoxy-2-hydroxymethyl-cyclohexa-2,4-dien-r-yl)-3ξ-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 61378-01-6 C₂₈H₂₈N₂O₅S₂ 
• 79355-33-2 Acetic acid (1S,6S)-5-chloromethyl-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-2,4-dienyl ester 
• 79355-33-2 Acetic acid (1S,6S)-5-chloromethyl-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-2,4-dienyl ester 
• 61377-99-9 Acetic acid (1S,6S)-5-hydroxymethyl-6-[(1R,3S,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-2,4-dienyl ester 
• 61378-02-7 C₂₁H₂₂N₂O₅S₂ 
• 61378-00-5 (1R,3S,5R)-6-((1S,6S)-2-Chloromethyl-6-hydroxy-cyclohexa-2,4-dienyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 61378-00-5 (1R,3S,5R)-6-((1S,6S)-2-Chloromethyl-6-hydroxy-cyclohexa-2,4-dienyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 61378-01-6 C₂₈H₂₈N₂O₅S₂ 
• 79355-33-2 Acetic acid (1S,6S)-5-chloromethyl-6-[(1R,3R,5R)-3-(4-methoxy-phenyl)-8-methyl-7,9-dioxo-2,4-dithia-6,8-diaza-bicyclo[3.2.2]non-6-yl]-cyclohexa-2,4-dienyl ester 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF GLIOTOXIN, DEHYDROGLIOTOXIN AND HYALODENDRIN

Two general methods, Method A and Method B in Scheme 19, to synthesize epidithiapiperazinediones, are described.A total synthesis of racemic and optically active gliotoxin (1) and of racemic dehydrogliotoxin (53) was achieved by using Method A, whereas a total synthesis of racemic hyalodendrin (52) was completed by using Method B.