79359-39-0

Upstream product

• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 137-07-5 2-amino-benzenethiol 
• 104-88-1 4-chlorobenzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Synthesis of 2-amino-4-phenyl-6-(phenylsulfanyl)-3,5-dicyanopyridines by tandem reaction

A novel basic ionic liquid, 1-(2-aminoethyl)pyridinium hydroxide, containing both Bronsted base and Lewis base sites has been used as an efficient catalyst for the synthesis of 2-amino-4-phenyl-6-(phenylsulfanyl)-3,5- dicyanopyridines. The condensation and oxidation tandem reaction of aldehydes, malononitrile, and thiols, performed in aqueous ethanol, afforded reasonable to good yields within 30-60 min. After the reaction, the catalyst could be recycled and reused. A possible mechanism to account for the tandem reaction is proposed. Graphical abstract: [Figure not available: see fulltext.].

K2CO3 catalyzed green and rapid access to 2-amino-3,5-dicarbonitrile-6-thio-pyridines

A series of 2-amino-3,5-dicarbonitrile-6-thio-pyridine derivatives have been synthesized by a simple method via a one-pot, three-component condensation reaction of aromatic aldehydes and malononitrile with substituted thiophenols using potassium carbonate as a green base in polyethylene glycol (PEG-400) as a reusable solvent. This protocol proved to be efficient and environmentally benign in terms of high yields, short reaction times, mild conditions, and reusability of the reaction medium.

Borax catalyzed domino reactions: Synthesis of highly functionalised pyridines, dienes, anilines and dihydropyrano[3,2-c]chromenes

Borax, an innocuous, inexpensive, and a naturally occurring material, very efficiently catalyzes the Knoevenagel condensation and Michael addition in domino fashion for the construction of highly functionalised pyridines, dienes, anilines and dihydropyran

Facile and rapid access to poly functionalized pyridine derivatives

An efficient and greener protocol for the synthesis of poly functionalized pyridines using tetra-n-butyl ammonium fluoride (TBAF) in water is established. Remarkable advantages of the present synthetic strategy over the others are shorter reaction times,

Application of unmodified microporous molecular sieves for the synthesis of poly functionalized pyridine derivatives in water

In the present work, catalytic activity of acidic as well as basic sites present over the microporous molecular sieves has been demonstrated. These acid-base sites display the combined catalytic reactivity in tap/deionized water for the efficient synthesi

Aqueous suspension of basic alumina: An efficient catalytic system for the synthesis of poly functionalized pyridines

In the present work, catalytic activity of basic alumina in water has been demonstrated for the synthesis of poly functionalized pyridines. This strategy has some remarkable advantages, such as use of heterogeneous catalyst in aqueous media, reusability o

Boric acid catalyzed convenient synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines in aqueous media

A one-pot three-component condensation of an aldehyde, malononitrile, and thiophenol has been achieved by conventional and ultrasound method. The reaction has been catalyzed by boric acid in aqueous medium. This protocol afforded corresponding 2-amino-3,5

DBU-catalyzed three-component one-pot synthesis of highly functionalized pyridines in aqueous ethanol

1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) efficiently catalyzes three-component one-pot condensations of aldehyde, malononitrile, and thiophenol to produce highly functionalized pyridines in excellent yield in aqueous ethanol.

One-step synthesis of heterocyclic privileged medicinal scaffolds by a multicomponent reaction of malononitrile with aldehydes and thiols

(Chemical Equation Presented) Heterocyclic privileged medicinal scaffolds involving pyridine, 1,4-dihydropyridine, chromeno[2,3-b]-pyridine, and dihydro-1,4-dithiepine frameworks are prepared via a single-step multicomponent reaction of structurally diver