79359-41-4

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 108-98-5 thiophenol 
• 109-77-3 malononitrile 
• 2826-25-7 2-(4-methylbenzylidene)malononitrile 

Downstream Products

• 1307285-63-7 5-amino-4-(4-methylphenyl)-2-phenylsulfanyl-6,7,8,9-tetrahydrobenzo[b][1,8]-naphthyridine-3-carbonitrile 
• 333781-43-4 2-amino-4-(4-methylphenyl)-6-sulfanylpyridine-3,5-dicarbonitrile 

Relevant academic research and scientific papers

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan

WEB (water extract of banana): An efficient natural base for one-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines

One-pot multi-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines derivatives using WEB (water extract of banana peels ash) as a green catalyst is described. A variety of aromatic aldehydes (with electron-donating and electron-withdrawing groups) in conjunction with aromatic and aliphatic thiols are known to tolerate this reaction condition using WEB. The reaction has simple work up procedure without using toxic solvents.

Amino-3, 5-dicyanopyridines targeting the adenosine receptors ranging from pan ligands to combined A1/A2B partial agonists

The amino-3,5-dicyanopyridine derivatives belong to an intriguing series of adenosine receptor (AR) ligands that has been developed by both academic researchers and industry. Indeed, the studies carried out to date underline the versatility of the dicyanopyridine scaffold to obtain AR ligands with not only a wide range of affinities but also with diverse degrees of efficacies at the different ARs. These observations prompted us to investigate on the structure–activity relationships (SARs) of this series leading to important previously reported results. The present SAR study has helped to confirm the 1H-imidazol-2-yl group at R2 position as an important feature for producing potent AR agonists. Moreover, the nature of the R1 substituent highly affects not only affinity/activity at the hA1 and hA2B ARs but also selectivity versus the other subtypes. Potent hA1 and hA2B AR ligands were developed, and among them, the 2-amino-6-[(1H-imidazol-2-ylmethyl)sulfanyl]-4-[4-(prop-2-en-1-yloxy)phenyl]pyridine-3,5-dicarbonitrile (3) is active in the low nanomolar range at these subtypes and shows a good trend of selectivity versus both the hA2A and hA3 ARs. This combined hA1/hA2B partial agonist activity leads to a synergistic effect on glucose homeostasis and could potentially be beneficial in treating diabetes and related complications.

Polysubstituted pyridine derivative and preparation method and application thereof

The invention discloses a polysubstituted pyridine derivative and a preparation method and the application thereof. The polysubstituted pyridine derivative adopts a structural formula 5. The preparation method comprises the following steps: in an organic

Unique role of 2-hydroxyethylammonium acetate as an ionic liquid in the synthesis of Fe3O4 magnetic nanoparticles and preparation of pyridine derivatives in the presence of a new magnetically recyclable heterogeneous catalyst

Abstract: In this paper, 2-hydroxyethylammonium acetate (2-HEAA) was used as the first functionalized ionic liquid for the facile, economical and environmentally friendly synthesis of Fe3O4 nanoparticles by a co-precipitation method. The synthesized Fe3O4 nanoparticles were used as solid material for supporting 2-HEAA (Fe3O4-2-HEAA). The newly prepared Fe3O4-2-HEAA was characterized by TEM, XRD, FT-IR, TGA and elemental analysis and successfully applied as a magnetically recyclable heterogeneous catalyst for the efficient one-pot, three-component synthesis of 2-amino-3,5-dicarbonitrile-6-thio-pyridines. The catalyst was easily separated by an external magnet and reused at least five times without significant degradation in the activity.

A convenient Baker yeast accelerated, one-pot synthesis of pentasubstituted thiopyridines

Here we report a novel Baker yeast catalyzed one pot cyclocondensation, performed at room temperature in ethanol for obtaining high yields of polyfunctionalized pyridines, 2-amino-4-aryl-3,5-dicyano-6-phenylthiopyridines. The developed protocol obeys cert

System and method for preparing 6-mercapto polysubstituted pyridine derivative through three-component one-pot reaction

The invention discloses a system and method for preparing a 6-mercapto polysubstituted pyridine derivative through a three-component one-pot reaction, belonging to the technical field of organic synthesis. The preparation system for the 6-mercapto polysubstituted pyridine derivative comprises a raw material mixing device, a microwave reaction device, a suction filtration device, a washing device and a vacuum drying device which are sequentially arranged, wherein the microwave reaction device is used for a microwave heating reaction of raw materials in the raw material mixing device; the suction filtration device is used for suction filtration of a reaction product; the washing device and the vacuum drying device are used for washing and vacuum drying of a filter residue obtained after filtering, respectively. According to the invention, aromatic aldehydes, malononitrile and mercapto compounds are used as reaction materials, and the 6-mercapto polysubstituted pyridine derivative is prepared under the catalysis of an alkaline ionic liquid catalyst. The catalyst used in the invention is high in catalytic activity and low in usage amount and cyclic loss; and the prepared derivate has high yield and high purity.

Heterogeneous Cu(II)/l-His@Fe3O4 nanocatalyst: A novel, efficient and magnetically-recoverable catalyst for organic transformations in green solvents

A novel, efficient and green Cu(ii)/l-His@Fe3O4 catalyst has been applied successfully in the synthesis of heterocyclic compounds. The resulting catalyst was used in the synthesis of 2,3-dihydroquinazolin-4(1H)-ones, polyhydroquinolines and 2-amino-6-(arylthio)pyridine-3,5-dicarbonitriles as biologically interesting compounds. The present research is focused on investigation of recycling, reusability and stability of the catalyst in phase reactions. The Cu(ii)/l-His@Fe3O4 catalyst was used at least six times with comparable activities to that of fresh catalyst. The chemical composition and the structure of the catalyst were analysed by TGA/DTG, EDS, XRD, VSM, FT-IR and SEM.

A green catalytic preparation 2-amino-4-phenyl-6 - (phenyl-yl) - 3,5-di-cyano pyridine derivatives

The invention discloses a green catalytic method for preparing 2-amino-4-phenyl-6-(phenylthio)-3,5-dicyanopyridine derivatives, belonging to the field of organic chemical synthesis. The method comprises the following steps: reacting aromatic aldehyde, mal

Cascade synthesis of thieno[2,3-b]pyridines by using intramolecular cyclization reactions of 3-cyano-2-(organylmethylthio)pyridines

2-Amino-4-aryl-6-mercaptopyridine-3,5-dicarbonitriles as starting materials have been prepared by reducing of 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitrile derivatives which were synthesized on stepwise one-pot three component reaction of malon