79359-70-9Relevant academic research and scientific papers
Efficient synthesis of thiopyrans using a sulfur-enabled anionic cascade
Li, Fang,Calabrese, David,Brichacek, Matthew,Lin, Ivy,Njardarson, Jon T.
supporting information; experimental part, p. 1938 - 1941 (2012/03/26)
The fifth element: An efficient new synthetic method for accessing 3,6-dihydro-2H-thiopyrans 1 in one pot has been developed. This method employs an anionic cascade, which is triggered by the addition of a vinyl nucleophile to a carbonyl group followed by S to O thiophosphate migration and an intramolecular thiolate displacement. The scope is demonstrated for a range of ketone and ester substrates.
