79361-03-8 Usage
Chemical Compound
2,2-difluoroglutaric anhydride is a chemical compound commonly used in organic synthesis for the preparation of fluorinated compounds.
Classification
It is classified as an anhydride, which means it is derived from the reaction of two carboxylic acid groups with the elimination of a molecule of water.
Structure
Its structure consists of a six-membered ring with two fluorine atoms attached to the alpha carbon.
Reactivity
2,2-difluoroglutaric anhydride is highly reactive due to the presence of the anhydride functional group.
Applications
It is used in the production of pharmaceuticals, agrochemicals, and other fine chemicals, and plays an important role in the development of fluorinated compounds with diverse applications in the fields of medicine, agriculture, and industry.
Functional Group
The anhydride functional group is responsible for its reactivity and ability to introduce fluorine atoms into organic molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 79361-03-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,3,6 and 1 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 79361-03:
(7*7)+(6*9)+(5*3)+(4*6)+(3*1)+(2*0)+(1*3)=148
148 % 10 = 8
So 79361-03-8 is a valid CAS Registry Number.
79361-03-8Relevant academic research and scientific papers
Moens, Matthias,Verniest, Guido,De Schrijver, Matthias,Ten Holte, Peter,Thuring, Jan-Willem,Deroose, Frederik,De Kimpe, Norbert
, p. 9284 - 9288 (2012)
A strategy toward the synthesis of functionalized 5,5-difluoropiperidines, a class of compounds with potential as building block in medicinal chemistry, was developed. In a three-step procedure 2,2-difluoroglutaric anhydride was synthesized starting from ethyl bromodifluoroacetate. This key intermediate reacts fluently with various imines to yield 5,5-difluoropiperidinone carboxylic acids. Subsequent esterification of the obtained carboxylic acids enabled the isolation of trans-substituted 5,5-difluoro-2-arylpiperidinone-3-carboxylates as the major isomers. Reduction of the difluorinated piperidinonecarboxylates using borane gave rise to new trans-2-aryl-1-benzyl-5,5-difluoro-3- hydroxymethylpiperidines in excellent yields.
