79362-44-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-Bromobenzoyl)pyridine is used as an intermediate for the production of pharmaceuticals due to its potential anti-inflammatory and antiproliferative properties. It plays a crucial role in the development of new drugs, particularly those targeting inflammation and cell proliferation-related disorders.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(3-Bromobenzoyl)pyridine is used as a building block for the synthesis of pesticides, herbicides, and fungicides. Its incorporation into these products helps in the development of more effective and targeted agrochemicals to protect crops and enhance agricultural productivity.
Used in Dye Industry:
3-(3-Bromobenzoyl)pyridine is also utilized in the manufacturing of dyes, where its unique chemical structure contributes to the color and properties of the final dye products. This application highlights its versatility and the broad range of industries that can benefit from its use.
Used in Organic Chemistry:
As a building block for chemical synthesis in organic chemistry, 3-(3-Bromobenzoyl)pyridine is employed in the creation of various other chemical compounds. Its presence in these syntheses allows for the development of new materials and compounds with diverse applications in research and industry.

InChI:InChI=1/C12H8BrNO/c13-11-5-1-3-9(7-11)12(15)10-4-2-6-14-8-10/h1-8H

Upstream product

• 1711-09-7 3-bromobenzoyl chloride 
• 626-55-1 3-Bromopyridine 
• 207681-67-2 N-methoxy-N-methyl-3-bromobenzamide 
• 89667-08-3 (3-bromophenyl)(3-pyridyl)methanol 
• 5424-19-1 3-Benzoylpyridine 

Downstream Products

• 79362-33-7 (E)-3-(3-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)allylamine 
• 79362-42-8 (Z)-3-(3-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)allylamine 
• 93943-82-9 (E)-7-(3-Bromo-phenyl)-7-pyridin-3-yl-hept-6-enoic acid 
• 1258203-12-1 C₁₃H₁₁BrN₄S 
• 1374583-25-1 (3-bromophenyl)(4-trifluoromethylphenyl)pyrid-3-yl methanol 
• 1374583-21-7 (3-bromophenyl)(4-chloro-2-fluorophenyl)pyrid-3-yl methanol 
• 1372806-03-5 C₁₄H₁₀BrN₃O₂ 
• 1372806-39-7 C₁₅H₁₃BrN₄O 
• 1372806-33-1 C₁₅H₁₂BrN₃OS 
• 1372806-18-2 C₁₅H₁₂BrN₃O₂ 
• 79362-51-9 [(Z)-3-(3-Bromo-phenyl)-3-pyridin-3-yl-allyl]-methyl-amine 
• 79362-68-8 1-(3-Bromo-phenyl)-1-pyridin-3-yl-prop-2-en-1-ol 

Relevant academic research and scientific papers

Analogues of fenarimol are potent inhibitors of trypanosoma cruzi and are efficacious in a murine model of chagas disease

We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC50s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chemically tractable, allowing rapid optimization of target biological activity and drug characteristics. Chemical and biological studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported.

Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L

A series of thiosemicarbazone analogs based on the benzophenone, thiophene, pyridine, and fluorene molecular frameworks has been prepared by chemical synthesis and evaluated as small-molecule inhibitors of the cysteine proteases cathepsin L and cathepsin B. The two most potent inhibitors of cathepsin L in this series (IC50 50 = 150.8 nM). Bromine substitution in the thiophene series results in compounds that demonstrate only moderate inhibition of cathepsin L. The two most active analogs in the benzophenone thiosemicarbazone series are highly selective for their inhibition of cathepsin L versus cathepsin B.

Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake

Analogues of the antidepressant agent zimelidine [6, (Z)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl)allylamine], a selective inhibitor of neuronal 5-hydroxytryptamine reuptake, were synthesized by several routes with the aim of obtaining compounds having a cis configuration (with respect to pyridyl and allylamine). Two methods utilized suitably substituted benzoylpyridines as starting materials. In two other routes, the bromine in 6 was either directly displaced (CN) or converted via the corresponding lithio derivative to H, Cl, I, Me, SiMe3. The configurations were determined by UV, 1H NMR and lanthanide-induced shifts in 1H NMR. The compounds were evaluated as uptake inhibitors by measuring the accumulation of [3H]noradrenaline and 5-hydroxyl[14C]tryptamine in mouse brain slices (in vitro and in vivo). Para substitution favored 5-hydroxytryptamine activity and ortho substitution favored NA activity in the cis series. The in vitro effect on 5-hydroxytryptamine was rather insensitive to variations in the para substituent, whereas pronounced effects in vivo were observed only with Cl, Br (6), and I.