793645-97-3

Upstream product

• 38989-02-5 (1S,4R)-1-amino-7,7-dimethyl-bicyclo[2.2.1]heptan-2-one 
• 137329-22-7 (+)-1-isocyanato-7,7-dimethylbicyclo[2.2.1]heptan-2-one 
• 178448-79-8 N-((1S,4S)-7,7-Dimethyl-2-methylene-bicyclo[2.2.1]hept-1-yl)-acetamide 
• 178448-80-1 (1S)-7,7-dimethyl-2-methyliden-1-norbornylamine 
• 154726-31-5 trifluoro-methanesulfonic acid (1S,4S)-7,7-dimethyl-2-methylene-bicyclo[2.2.1]hept-1-yl ester 
• 7787-20-4 (1R)-fenchone 
• 178603-08-2 (1R)-7,7-dimethyl-2-oxo-1-norbornylamine 
• 21286-54-4 Camphorsulfonyl chloride 
• 3144-16-9 (1S)-10-camphorsulfonic acid 
• 464-78-8 (1S)-(+)-ketopinic acid 

Downstream Products

• 292039-09-9 (1S,5R,7R)-10,10-dimethyl-3-ethyl-4-oxa-2-azatricyclo[5.2.1.0^1,5]dec-2-ene 

Relevant academic research and scientific papers

Camphor Schiff base, and preparation method and application thereof

The invention discloses camphor Schiff base, and a preparation method and application of the camphor Schiff base. A structural formula of the camphor Schiff base is as shown in the description. The preparation method the camphor Schiff base comprises the

Cu-catalyzed asymmetric Henry reaction promoted by chiral camphor Schiff bases

Five novel chiral camphor Schiff bases have been synthesized and utilized as ligands in asymmetric Henry reaction between nitromethane and aldehydes. The diastereoisomeric Schiff bases 5a and 5a' were separated successfully and gave completely different a

Enantioselective addition of dialkylzinc to aromatic aldimines mediated by camphor-derived chiral β-amino alcohols

The enantioselective addition of diethylzinc or dimethylzinc to N-(diphenylphosphinoyl)imines mediated by 1 or 2 could be achieved in high yields (70-97%) and enantioselectivities (85-98% ee). The catalytic loading of 1 or 2a could be reduced to 10 mol% f

METHOD OF ENANTIOSELECTIVE ADDITION TO IMINES

The present invention relates to a method of enantioselective addition to imines, including: reacting R2CH═NY with R3ZnR4 in the presence of a compound represented by the following formula (I), in which Y, R1, R

A new chiral oxazoline derived from camphor and its conversion to (R)-2-methylalkanoic acids

(1S,5R,7R)-(-)-10,10-Dimethyl-3-ethyl-4-oxa-2-azatricyclo[5.2.1.01,5]dec-2-ene 2 was prepared in 95% yield from (1S)-1-amino-2-exo-hydroxyapocamphane 1. The chiral oxazoline could be alkylated (LDA/THF/-78°C/RX, RX=ethyl, n-propyl, n-butyl iodides or benzyl bromide) to 3 in 95% yield and >95% diastereoselectivity, and the products hydrolysed to (R)-2-methylalkanoic acids 4 (43-47% yield, 93-98% e.e.). Copyright (C) 2000 Elsevier Science Ltd.

A facile synthesis of new homochiral β-amino alcohols with norbornane framework

New homochiral 1,2-amino hydroxy derivatives of norbornane are easily prepared starting from naturally occurring 2-norbornanones.

Synthesis of several novel optically active nitroxyl radicals

Optically active nitroxyl radicals are prepared from enantiomerically pure bicyclic tempenoids. (-)-Camphoxyl radical (-)-4 derived from commercially available oxazolidinone (-)-1 and (+)-camphoxyl radical (+)-4 derived from (-)-camphene are readily prepared, conformationally rigid, enantiomeric nitroxyl radicals. (-)-Camphorsulphonic acid is used to prepare two additional optically active nitroxyl radicals 9 and 12.

Asymmetric aldol reactions: A novel model for switching between chelation- and non-chelation-controlled aldol reactions

A new camphor-based N-propionyloxazolidinethione provides remarkable levels of asymmetric induction for both chelation- and non-chelation-controlled aldol processes. While the aldol condensation of the derived di-n-butylboryl enolate with various aldehyde

"Non-Evans" syn aldol via aldolization of chlorotitanium enolate with TiCl4/ aldehyde complex

Direct aldolizations of chlorotitanium enolate derived from camphor-based oxazolidinethione with 1:1 TiCl4-aldehyde complex give "non-Evaner" syn aldol with excellent diastereoselectivity.