793670-71-0Relevant academic research and scientific papers
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors
Lovell, Peter J.,Blaney, Frank E.,Goodacre, Caroline J.,Scott, Claire M.,Smith, Paul W.,Starr, Kathryn R.,Thewlis, Kevin M.,Vong, Antonio K.K.,Ward, Simon E.,Watson, Jeannette M.
, p. 1033 - 1036 (2007/10/03)
Investigation of halogen substitution in lead compound 1 has led to the identification of analogues which combine high affinity for 5-HT1A receptors and potent serotonin reuptake inhibitory activity. Several compounds show an improved selectivity over 5-HT1B and 5-HT1D receptors and a superior pharmacokinetic profile in the rat.
BENZOXAZINONE DERIVATIVES HAVING AFFINITY FOR 5- HT RECEPTORS, THEIR PREPARATION AND USE
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Page 11-12, (2010/02/09)
Benzoxazinone derivatives, their preparation and use Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: (I) wherein R1 is hydrogen or C1-6alkyl; R2 is fluoro or chloro; R3 is hydrogen, fluoro or chloro; and X is nitrogen
