793686-33-6Relevant academic research and scientific papers
Efficient chemoenzymatic enantioselective synthesis of diacylglycerols (DAG)
Guanti, Giuseppe,Banfi, Luca,Basso, Andrea,Bevilacqua, Elisabetta,Bondanza, Laura,Riva, Renata
, p. 2889 - 2892 (2004)
A new efficient chemoenzymatic methodology for the production of 3-O-benzyl-sn-glycerol and 1,2-O-dipalmitoyl-sn-glycerol has been developed. It starts from racemic 1-O-benzylglycerol and is based on the sequential enzymatic acylation-Mitsunobu inversion-enzymatic hydrolysis, which has been performed without isolation of the intermediates. In this way a 70-75% yield of 3-O-benzyl-sn-glycerol with 94-96% ee has been obtained.
