793726-84-8

Basic information

• Product Name: BIBU 1361 DIHYDROCHLORIDE
• Synonyms: N-(3-CHLORO-4-FLUOROPHENYL)-6-[4-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]-PYRIMIDO[5,4-D]PYRIMIDIN-4-AMINE DIHYDROCHLORIDE;BIBU 1361 DIHYDROCHLORIDE;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-aminedihydrochloride;N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]pyrimido[5,4-d]pyrimidin-4-amine;BIBU 1361
• CAS NO: 793726-84-8
• Molecular Formula: C22H29Cl3FN7
• Molecular Weight: 516.8699632
• Mol File: 793726-84-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 663.5°C at 760 mmHg
• Flash Point: 355.1°C
• Appearance: /
• Vapor Pressure: 7.65E-18mmHg at 25°C
• Storage Temp.: Desiccate at +4°C
• Solubility: DMSO (Slightly), Methanol (Very Slightly)
• CAS DataBase Reference: BIBU 1361 DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIBU 1361 DIHYDROCHLORIDE(793726-84-8)
• EPA Substance Registry System: BIBU 1361 DIHYDROCHLORIDE(793726-84-8)

Safety Data

• Hazardous Substances Data: 793726-84-8(Hazardous Substances Data)

Usage

Uses

BIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation.

Biological Activity

Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC 50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC 50 > 10 μ M). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice.

references

[1]. antczak c, mahida jp, bhinder b, et al. a high-content biosensor-based screen identifies cell-permeable activators and inhibitors of egfr function implications in drug discovery. journal of biomolecular screening, 2012, 17(7): 885-899.[2]. ghildiyal r, dixit d, sen e. egfr inhibitor bibu induces apoptosis and defective autophagy in glioma cells. molecular carcinogenesis, 2013, 52(12): 970-982.

InChI:InChI=1/C22H27ClFN7.4ClH/c1-3-30(4-2)13-15-7-9-31(10-8-15)22-25-12-19-20(29-22)21(27-14-26-19)28-16-5-6-18(24)17(23)11-16;;;;/h5-6,11-12,14-15H,3-4,7-10,13H2,1-2H3,(H,26,27,28);4*1H