79384-95-5Relevant academic research and scientific papers
Oxidative cyclization of tertiary pentenol derivatives forming 2,5,5-trisubstituted THF rings and the total synthesis of cyclocapitelline
Phillips, Geoffrey A.,Palmer, Cory,Stevens, Andrew C.,Piotrowski, Mathew L.,Dekruyf, Daryl S.R.,Pagenkopf, Brian L.
, p. 6052 - 6055 (2015)
The synthesis of 2,5,5-trisubstituted tetrahydrofuran rings was accomplished via the Mukaiyama aerobic oxidative cyclization of tertiary 5-pentenols employing the Co(nmp)2 catalyst. A variety of THFs were formed in moderate to good yield and diastereoselectivity. The method developed herein was successfully applied to an enantioselective total synthesis of cyclocapitelline.
