79387-71-6Relevant articles and documents
Highly sensitive fluorescent sensor targeting CuCl2based on thiophene attached anthracene compound (TA)
Nguyen, Thuy Van Thi,Seo, Young Jun
, p. 941 - 944 (2017)
A novel thiophene attached anthracene (TA) based fluorescent compound was designed and synthesized. The TA showed a high quantum yield (Qy?=?0.34) in regard to fluorescence. We applied this TA compound to detect specific metal compound and found that it could identify CuCl2from other metals through dramatic fluorescence change at λmax?=?460?nm. It showed strong quenching fluorescence property with CuCl2while with other metal compounds it exhibited strong blue fluorescence emission. UV/Vis absorption spectroscopy clearly demonstrated that the quenching property of TA at λmax?=?460?nm was due to overlapping of the fluorescence peak of TA at λmax?=?460?nm and the absorption band of CuCl2(from 190?nm to 525?nm). Binding constant (K′), which was 0.0895?mM?2, indicated a complexation ratio between TA and CuCl2as 1:2 and this interaction induced quenching property.
Novel indole-based photosensitizers coupled with PEG-HEC quasi-solid-state electrolyte to improve energy conversion and stability of organic dyes based-dye sensitized solar cells
Santhosh, Kamaraj,Ganesan, Shanmugam,Balamurugan, Selvaraj
, (2021/07/13)
A series of novel Indole based organic dyes were synthesized and coupled with a Poly-ethylene glycol-Hydroxy ethyl cellulose quasi-solid-state-electrolyte (PEG-HEC QSSE) polymer blended iodine electrolyte to obtain a metal-free dye-based dye-sensitized so
Novel M2-selective, Gi-biased agonists of muscarinic acetylcholine receptors
Randáková, Alena,Nelic, Dominik,Ungerová, Dana,Nwokoye, Peter,Su, Qiwen,Dole?al, Vladimír,El-Fakahany, Esam E.,Boulos, John,Jakubík, Jan
supporting information, p. 2073 - 2089 (2020/02/18)
Background and Purpose: More than 30% of currently marketed medications act via GPCRs. Thus, GPCRs represent one of the most important pharmacotherapeutic targets. In contrast to traditional agonists activating multiple signalling pathways, agonists activating a single signalling pathway represent a new generation of drugs with increased specificity and fewer adverse effects. Experimental Approach: We have synthesized novel agonists of muscarinic ACh receptors and tested their binding and function (on levels of cAMP and inositol phosphates) in CHO cells expressing individual subtypes of muscarinic receptors, primary cultures of rat aortic smooth muscle cells and suspensions of digested native tissues from rats. Binding of the novel compounds to M2 receptors was modelled in silico. Key Results: Two of the tested new compounds (1-(thiophen-2-ylmethyl)-3,6-dihydro-2H-pyridinium and 1-methyl-1-(thiophen-2-ylmethyl)-3,6-dihydro-2H-pyridinium) only inhibited cAMP synthesis in CHO cells, primary cultures, and native tissues, with selectivity for M2 muscarinic receptors and displaying bias towards the Gi signalling pathway at all subtypes of muscarinic receptors. Molecular modelling revealed interactions with the orthosteric binding site in a way specific for a given agonist followed by agonist-specific changes in the conformation of the receptor. Conclusions and Implications: The identified compounds may serve as lead structures in the search for novel non-steroidal and non-opioid analgesics acting via M2 and M4 muscarinic receptors with reduced side effects associated with activation of the phospholipase C signalling pathway.
