79391-97-2Relevant academic research and scientific papers
Approach to the Total Synthesis of Chlorothricolide: Synthesis of "7-epi-Bottom Half" and Its Union with "Top Half" Systems
Ireland, Robert E.,Thompson, Wayne J.,Srouji, Gabriel H.,Etter, Rolf
, p. 4863 - 4873 (2007/10/02)
A synthesis of the "bottom half" of the antibiotic aglycon chlorothricolide (1) is described.Compound 1 was prepared in 13 steps from the readily available hydrobenzsuberone system 8; the process entails the stereoselective conjugate addition of magnesium bromide to form the C ring.Union of the "top" and bottom" halves and decarbonylation of the derived aldehyde are explored.
