79397-21-0

Upstream product

• 106-48-9 4-chloro-phenol 
• 122-88-3 4-Chlorophenoxyacetic acid 
• 2381-75-1 (4-chlorophenoxy)acetic acid hydrazide 

Downstream Products

• 79397-25-4 2-[2-(4-Chloro-phenoxy)-acetylamino]-3-(1H-indol-3-yl)-propionic acid methyl ester 
• 81866-04-8 1-Chloro-4-isocyanatomethoxy-benzene 
• 1610785-15-3 1-((4-amino-2-methylpyrimidin-5-yl)methyl)-3-((4-chlorophenoxy)methyl)urea 
• 79397-31-2 2-[2-(4-Chloro-phenoxy)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 79397-27-6 1-[2-(4-Chloro-phenoxy)-acetyl]-pyrrolidine-2-carboxylic acid methyl ester 
• 79397-24-3 2-[2-(4-Chloro-phenoxy)-acetylamino]-3-hydroxy-propionic acid methyl ester 
• 79397-30-1 2-[2-(4-Chloro-phenoxy)-acetylamino]-3-(4-hydroxy-phenyl)-propionic acid methyl ester 
• 79397-26-5 N-(p-chlorophenoxyacetyl)phenylalanine methyl ester 
• 79397-23-2 2-[2-(4-Chloro-phenoxy)-acetylamino]-4-methyl-pentanoic acid methyl ester 
• 79397-22-1 [2-(4-Chloro-phenoxy)-acetylamino]-acetic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 inhibitors

By targeting the ThDP binding site of Escherichia coli PDHc-E1, two new 'open-chain' classes of E. coli PDHc-E1 inhibitors, amide and urea derivatives, were designed, synthesized, and evaluated. The amide derivatives of compound 6d, with 4-NO2 in the benzene ring, showed the most potent inhibition of E. coli PDHc-E1. The urea derivatives displayed more potent inhibitory activity than the corresponding amide derivatives with the same substituent. Molecular docking studies confirmed that the urea derivatives have more potency due to the two hydrogen bonds formed by two NH of urea with Glu522. The docking results also indicate it might help us to design more efficient PDHc-E1 inhibitors that could interact with Glu522.

Synthesis of Amino Acid Derivatives of (p-Chlorophenoxy)- and (4-Chloro-3-sulphophenoxy)-acetic Acids

Syntheses of some (p-chlorophenoxy)acetylamino acids and (3-N-sulphonylamino acid-4-chlorophenoxy)acetic acid derivatives (IV-XXXI) are described.Compounds XX-XXXI have been found to be biologically active against a number of microorganisms.