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Downstream Products

• 61832-58-4 3-(3,4-dimethoxyphenyl)piperidine 
• 103150-12-5 1(R),3(R)-(α-methoxy-α-phenylacetyl)-3-(3,4-dimethoxyphenyl)piperidine 
• 103150-11-4 1(R),3(S)-(α-methoxy-α-phenylacetyl)-3-(3,4-dimethoxyphenyl)piperidine 

Relevant academic research and scientific papers

4(or 3)-(3,4-Dihydroxyphenyl)pyridines, their cardiotonic use and cardiotonic use of their methyl ethers

4(or 3)-(3,4-Dihydroxyphenyl)pyridine, a cardiotonic agent, is prepared by demethylating 4(or 3)-(3,4-dimethoxyphenyl)pyridine, preferably by heating with aqueous hydrogen bromide. 4(or3)-[3,4-di-(OR)-phenyl]pyridine, where R is hydrogen or methyl, or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in a cardiotonic composition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient requiring such treatment. The novel isomeric 2-[3,4-di-(OR)-phenyl]pyridine, where R is hydrogen or methyl, is shown for comparative purposes.